Postdoctoral Research Associate
Applications are invited for the position of Post-Doctoral Research Assistant in the Diabetes Research Group at King’s College London, working in the laboratory of Professor Peter Jones in collaboration with Dr Chloe Rackham at the University of Exeter on a project entitled “ Improving beta cell function by mesenchymal stromal cells: novel mechanisms and cell-free translational potential”. The project is focused on improving human islet transplantation as a therapy for type 1 diabetes and will investigate the mechanisms of how mesenchymal stromal cells improve the functional survival of human islets in vitro and in vivo. The postholder will have a background in in vitro assessment of cell function and a knowledge of mouse models of islet transplantation.
Minimum qualifications are a PhD in a relevant subject with molecular/cell biology skills and an interest in translating in vitro observations into in vivo models.
• PhD in a relevant biomedical sciences subject.
• Expertise in in vitro assessment of cell function.
• Prior experience with isolating and using islet of Langerhans would be an advantage.
• Home Office Licence would be an advantage.
This post will be offered on an a fixed-term contract until 30 Sep 2023.
This is a full-time post - 100% full time equivalent
• Management of the research project on a day-to-day basis, maintaining lines of communication with Prof Jones and Dr Rackham.
• Integrating with the wider Department of Diabetes at King’s College London.
• Liaising with the University of Exeter, including short research visits.
• Supervision of MSc/BSc students where required.
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
1. Expertise in general molecular cell biology techniques such as cell/tissue culture, qRT-PCR, immunoblotting, immunoassays, (immuno)histochemistry.
2. Expertise in in vitro assessment of cell function including viability, apoptosis, proliferation, ATP generation, secretory capacity.
3. Willingness to contribute to in vivo studies of islet transplantation in mouse models of diabetes.
4. Willing and able to work in a team.
5. Ability to keep clear and well-organized laboratory notes and records.
6. Ability to plan and prioritise workload.
7. Good communication (both written and verbal) and presentation skills.
8. Self-motivated, ability to work independently.
• Experience with isolating and using islet of Langerhans.
• Experience in isolating and characterizing extracellular vesicles.
• Experience of using mouse models for metabolic studies, or for islet transplantation studies.
Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.