Skip to main content

This job has expired

Research Associate in Tumour Immunology Group

Employer
KINGS COLLEGE LONDON
Location
London (Greater)
Salary
£39,345 per annum, including London Weighting Allowance
Closing date
3 Oct 2021

View more

Academic Discipline
Biological Sciences, Life sciences
Job Type
Research Related, Research Associate
Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description
The Tumour Immunology Group at King’s College London ( https://www.kcl.ac.uk/lsm/research/divisions/cancer/research/groups/tig) have an opportunity for a Postdoctoral Associate to join their team. The post, which is a FTE fixed term contract for 3 years, will utilise in vivo models of cancer to investigate the immune-stimulating effects of chemotherapy for improving responses to immunotherapy treatments as part of drug combinations.
 
Chemotherapeutic drugs can be immune-stimulatory and, as such, can be used alongside immunotherapy approaches to improve clinical outcomes. However, the rules for the chemotherapy-elicited immune responses are still poorly understood. It is also clear that the stromal microenvironment of the tumour influences these responses. This project will explore the immune-stimulatory capabilities of standard-of-care chemotherapy drugs using preclinical models of cancer to improve our understanding of how to predict these responses and inform how to more efficiently uses cytotoxic chemotherapies within novel immunotherapy drug combinations and adoptive cell therapies.
 
The project will utilize novel genetic models to study the immune-stimulating effects of chemotherapy with the aim to uncover previously unappreciated mechanisms through which these drugs contribute to anti-tumoral immune responses. The project will involve single cell RNAseq, flow cytometry and imaging techniques. The post will be primarily based on the Guy’s Campus within the School of Cancer and Pharmaceutical Sciences. The candidate will work closely with the principle investigator Dr James Arnold and other members of the Team. The candidate will more broadly benefit from the interdisciplinary research and academic networks at King’s College London.
 
The successful candidate must have (or be about to receive) a PhD relating to a tumour and/or immunology subject. Candidates should have previous experience with single cell RNAseq and imaging techniques. Previous experience in intravital imaging would be highly regarded (but not essential).
 
This post will be offered on a fixed-term contract for 36 months
This is a full-time post - 100% full time equivalent

Key responsibilities
The successful applicant will be responsible for:  
•       The day to day running of the project 
•       Conducting experiments, analysing data and presenting to the supervisor 
•       Supporting more junior members of the laboratory team 
•       Working towards meeting project milestone deadlines 
 
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  
 
Skills, knowledge, and experience 


Essential criteria 
The applicant must have: 
•       A PhD in a relevant area  
•       A good track record of research in a cancer and/or immunology-related subject. 
•       Experience using in vivo models (ideally relating to cancer). 
•       Experience in imaging techniques. 
•       Experience in single cell RNAseq. 
 
Desirable criteria 
•       Hold a Home Office Personal Licence  
•       To have a publication in a respected journal 
•       To be able to perform computational analyses associated with scRNAseq 
 
* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6. 
 
Further information
Interviews will be held remotely in late August/early September and will include a 10-minute presentation of a previous research project that the applicant has conducted.  

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert