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Clinical Trials Statistician

Employer
KINGS COLLEGE LONDON
Location
London (Greater) (GB)
Salary
£38,304 - £45,026 per annum, including London Weighting Allowance
Closing date
15 Aug 2021

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Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description

About us:

The Cancer Research UK & King’s College London Cancer Prevention Trials Unit (CPTU) specialises in research to advance cancer prevention, early diagnosis and screening.  We perform research on efficacy, cost-effectiveness and technologies to improve existing and establish new screening programmes.

Our portfolio of both secondary (hospital) and primary (community) care trials includes:

  • Multi-centre international randomised controlled trials of medicinal prevention of cancer often using drug re-purposing
  • Pragmatic trials of screening and diagnostic interventions
  • Trials of behavioural interventions in cancer prevention and screening
  • Trials of diagnostic/screening devices

About the role:

We are looking for an enthusiastic trial statistician to join the CPTU team to provide statistical support for our cancer screening research projects.

You will be the trial statistician on projects including the NHS-Galleri trial: a randomised controlled trial of a multi-cancer early detection test with GRAIL Bio UK Ltd, NHS England and NHS Improvement.  Over 700,000 people across England will be invited to receive a novel CE-marked, blood test for the presence of over 50 cancers. We have other new exciting projects prevention and early detection of prostate, bladder, cervical cancer.

The successful applicant will join the CRUK & King’s College London Cancer Prevention Trials Unit under the leadership of Professor Sasieni at King’s College London.

The post holder will be a statistician with a strong interest in clinical trials.  You  will be primarily working on analyses of data from cancer screening trials and other studies in cancer prevention. This will require a good understanding of statistical methods and fluency in using statistical software (e.g. R and/or Stata). You will have excellent organisational and planning skills with an intrinsic interest in improving the health and well-being of communities through translational research and evidence-based innovation.

You will oversee statistical activities for major projects, supporting the development of trial protocols and statistical analysis plans, preparing reports for data monitoring committees and being responsible for carrying out interim and main statistical analyses.  You will lead on the tables, listings, and figures (TLFs) displaying all study data and results in the clinical study report (CSR).

Contributions to applied analyses or methodological development will be recognised through authorship on publications. Opportunities will also be provided for further professional development.

The person appointed will report to and be supervised by Dr Bernard North, Senior CPTU Statistician, and will work closely with trial teams and data managers.

This post is currently home-working in response to COVID-19.  For this reason, the postholder must be self-motivated and be able to work independently.

More details can be found at

https://www.kcl.ac.uk/lsm/research/divisions/cancer/research/groups/canprev/Cancer-Prevention-Group.aspx   

This post will be offered on a fixed-term, full time contract until 30 April 2024.

Key responsibilities

Responsible for day-to-day statistical activities:

  • To contribute to study design, data manipulation, writing statistical analysis plans, undertaking statistical analyses, interpretation of results and solving statistical problems that may arise.
  • To contribute to the preparation of clinical study reports
  • To contribute to the writing and publication of high-quality papers in peer-reviewed literature and the dissemination of research findings.
  • To maintain accurate written and computerised records and to maintain confidentiality of all electronically stored personal data in line with relevant information governance policies and  ensure confidentiality on all matters and information obtained during the course of employment.
  • To contribute to the development and dissemination of sound methodology appropriate to the group’s portfolio of studies.
  • Work, where applicable, with the Sponsor, Chief Investigator(s), grant co-applicants, data managers, monitors, clinicians, statisticians and trial oversight committees and external agencies on a daily basis to ensure the project milestones are met
  • Responsible for the development of statistical procedures for the conduct of the protocol
  • Ensure that the trial protocol is conducted in accordance with the applicable ethical, regulatory and quality standards and that appropriate records and audit trails are maintained
  • Prepare trial reports as required
  • Work closely with the trial and data managers to ensure timely data entry and cleaning and to ensure satisfactory resolution
  • Approve case report forms to ensure all relevant data is collected to answer the research objectives
  • Support the data managers to decide what steps need to be taken to correct any missing, contradictory or incorrect data and ensure that these problems are followed through to a satisfactory conclusion within a reasonable timescale
  • Ensure that the collection of trial data is complete, accurate and up to date for analysis according to agreed deadlines.
  • The post-holder will be expected to work both independently in planning day-to-day activities (in accordance with the projects’ deadlines as agreed with their supervisor) and as part of a multidisciplinary research team.
  • Any other duties appropriate to the grade as directed by the line manager and CPTU Head of Operations

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

1.       Degree-level qualification in statistics, mathematics or with a substantial statistical and data analysis content

2.       PhD with high statistics content or have equivalent experience

3.       A solid understanding of statistical concepts especially when applied to biomedical research

4.       A strong background in  clinical trial design, conduct, analysis and interpretation

5.       Excellent written and verbal communication skills, including ability to convey statistical concepts to a non-statistical audience

6.       Proficiency in using statistical software (ideally Stata)

7.       Experience in manipulating data sets and in analysing research data 

8.       High level of accuracy and attention to detail

9.       Willingness to learn new software (e.g. Stata if not already known) and advanced statistical methods

10.   Highly motivated, hardworking, adaptable, problem-solving with a high level of accuracy and attention to detail 

11.   Ability to work both independently and as part of a multidisciplinary team 

12.   Peer-reviewed publications

Desirable criteria

1.       Knowledge of the use of genetic and epigenetic biomarkers particularly in cancer diagnosis and prognosis.

2.       Knowledge of cancer diagnostic and treatment pathways and data repositories.

3.       Knowledge of the development and assessment of clinical prediction models.

4.       Good knowledge of at least one programming language (e.g. C++ or Stata/Mata)

5.       Experience working as a statistician in a research environment (academic or commercial) 

6.       Knowledge of statistical methods for the analysis of missing values

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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