PhD Studentship, Cancer Sciences
Location: Southampton General Hospital
Closing Date: Friday 11 June 2021
Engineering novel chimeric antigen receptor (CAR) T cells for immunotherapy of acute myeloid leukaemia (AML)
Lead Institute / Faculty: Medicine
Main Supervisor: Dr Ali Roghanian
Other members of the supervisory team: Prof Mark Cragg and Prof Björn Frendéus
Amount of stipend and fees: £15,609 plus £2,500 uplift including tuition fees for 42 months
Acute Myeloid Leukaemia (AML) remains an unmet medical need with ~3,500 new cases and ~1% of all new cancer deaths in the UK alone each year. Current treatments for AML fail to induce long-term tumour regression, demonstrating the need for new therapies. Chimeric antigen receptor (CAR) T-cell therapy is one approach currently being actively investigated for AML immunotherapy following clinical successes in B-cell malignancies. This therapy combines antibody specificity and T cell cytotoxicity to elicit a targeted therapeutic response.
In collaboration with our industrial partner, BioInvent International (Lund, Sweden), we previously produced and extensively characterised a unique panel of monoclonal antibodies (mAb) against human AML surface antigens. By taking advantage of these unique reagents and preclinical models of AML (xenograft and humanised mice) available at Southampton, this MRC iCASE PhD project aims to investigate the efficacy and safety profiles of autologous CAR-T cells against human AML.
Please contact: Dr Ali Roghanian (A.Roghanian@soton.ac.uk)
Person Specification: See below
The successful candidate is likely to have the following qualifications:
- A 1stor 2:1 degree in a relevant discipline and/or second degree with a related Masters
Medical Research Council iCASE in collaboration with industrial partner BioInvent International.
Administrative contact and how to apply:
Please complete the University's online application form, which you can find at
You should enter Dr Ali Roghanian as your proposed supervisor. To support your application provide an academic CV (including contact details of two referees), official academic transcripts and a personal statement (outlining your suitability for the studentship, what you hope to achieve from the PhD and your research experience to date).
Closing date: 11/06/2021
Interview date: 17/06/2021