NATIONAL UNIVERSITY OF SINGAPORE

Research Fellow, Pharmacy

Location
Singapore
Posted
10 May 2021
End of advertisement period
09 Jun 2021
Ref
3622344
Contract Type
Permanent
Hours
Full Time

Job Description

The successful candidate will work with Assistant Professor Brandon I Morinaka on the production and characterization of a new class of cyclic peptides using posttranslational modifying enzymes under a project on Next-generation peptides for infectious diseases.

The RF will be responsible for leading a project that involves the formation of novel cyclic peptides using enzymes. The cyclic peptides will be produced by either heterologous expression in Escherichia coli - or - by using purified enzymes. The subsequent products will be purified by chromatographic techniques and the structures determined by spectroscopic methods (LC-MS, NMR, and degradation/synthesis). Finally, the peptide products will be tested in bioassays relevant to infectious diseases for the identification of new bioactive peptides. The candidate should have a strong background in natural products chemistry or biosynthesis, excellent communication skills, and the ability to work in a team.

Other responsibilities include training of students/staff and maintenance/repair of equipment.

Qualifications

Qualifications / Discipline:

The candidate must possess a PhD in the Sciences with a focus on biochemistry/molecular biology, chemical biology, natural products chemistry/biosynthesis, or a field relevant to the research

Skills:

  • Analytical chemistry (HPLC, Mass spectrometry, and Nuclear magnetic resonance). 
  • Molecular biology and biochemistry (cloning, PCR, protein expression, SDS-PAGE, CRISPR/CAS9)

Experience:

  • Bioinformatic analysis of natural product gene clusters. 
  • Isolation and structure elucidation of natural products. 
  • Cloning and expression of natural product enzymes and pathways.

More Information

Location: Kent Ridge Campus
Organization: Science
Department: Pharmacy
Employee Referral Eligible: No

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