NATIONAL UNIVERSITY OF SINGAPORE

Research Fellow, Research

Location
Singapore
Posted
01 Mar 2021
End of advertisement period
31 Mar 2021
Ref
3605744
Contract Type
Permanent
Hours
Full Time

Job Description

A postdoctoral position is available immediately in Dr Yvonne Tay’s lab for a highly motivated Ph.D. or M.D graduate with a background in molecular or cellular biology, biochemistry or other related fields who is interested in deciphering post-transcriptional networks encompassing mRNAs, non-coding RNAs, RNA binding proteins and RNA processes such as splicing and editing in cancer (reviewed in Tay et al, Nature 2014; also see Chan et al, Nucleic Acids Res 2018 and Kwok et al, Cancer Res 2020). The successful candidate should be interested in understanding tumor heterogeneity at a single cell level, as well as developing RNA-based diagnostics and therapeutics. He/She will work with long-read sequencing data, design and conduct experiments, analyse data, write papers and grants, mentor students, and compete for fellowships.

The Tay lab is in the Cancer Science Institute of Singapore, a state-of-the-art research center with a multifaceted and coordinated approach to cancer research, extending from basic cancer studies all the way to experimental therapeutics. The focus of the institute is on cancers endemic to Asian populations such as gastric, liver, lung, leukemia and breast cancers. The institute houses a full spectrum of research and clinical translational facilities. This major center is led by a team of world-class scientists with significant government funding from Singapore’s National Research Foundation and Ministry of Education.

Qualifications

  • A Ph.D. in cancer biology or related area
  • Experience with in vivo animal models, particularly mice
  • Expertise in RNA biology is preferred
  • Strong background and working knowledge of basic molecular and cellular biology techniques such as cell culture, cloning, real-time PCR and western blotting
  • Experience with analyses of human clinical samples, single cell sequencing, long-read sequencing, RNA immunoprecipitation, mass spectrometry and/or CRISPR genome editing is highly desirable
  • Ability to independently lead research projects and critically analyse data
  • A proven track record in the form of publications in top international English language journals
  • Ability to communicate in written and spoken English

Applications should be sent to yvonnetay@nus.edu.sg with the subject ‘Application for postdoc position in YT lab’, and should include full curriculum vitae, publication list, and names and contact information of 3 referees. Please also include a summary of your research experience.

More Information Related publications:

  • Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455(7216),1124-1128.
    • Selected by Faculty of 1000
  • Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147, 344–357.
    • Selected by Faculty of 1000
  • Tay Y, Rinn J, Pandolfi PP. (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature. 505, 344-352. Chan JJ, Kwok ZH, Chew XH, DeNicola G, Yang H, Tay Y. (2018) A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer. Nucleic Acids Research. 46(4), 1998-2011.

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