KINGS COLLEGE LONDON

Research Associate - Developmental Neurobiology

4 days left

Location
London (Central), London (Greater)
Salary
£38,304 to £41,517, including London Weighting Allowance
Posted
21 Jan 2021
End of advertisement period
28 Feb 2021
Ref
013764
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

The Houart lab is seeking to appoint three postdoctoral research associates (PDRA) to join a Wellcome Trust-funded research programme aiming to understand the role of axonal splicing factors and intron retaining transcripts in neuronal maturation, establishment and maintenance of neuronal connectivity. Our nervous system crucially relies on local fast decisions taken at synapses, long distance from the neuronal cell body. The mechanisms by which these decisions are spatio-temporally controlled remain obscure. Axonal splicing factors and intron-retaining mRNAs have newly been identified as key players in the process. We seek to understand the fundamental molecular and cellular roles they play locally in the dynamic control of neuronal connectivity, using animal models (zebrafish) and cell culture approaches.

The research programme will require expertise in genetics, transcriptomics, proteomics, high-resolution (live and fixed) molecular imaging, computational analytical methods. We wish to appoint a PDRA with expertise in cutting-edge imaging technology, a PDRA with strong zebrafish neurobiology background and a PDRA with very strong protein/RNA biology experience.

The Houart lab is a long-term member and Deputy Head of the outstanding Centre for Developmental Neurobiology and MRC Centre for NeuroDevelopmental Disorders and is attached to the Francis Crick Institute. This environment provides world-class research facilities essential for this ambitious research programme.

For further information, please contact Prof. Corinne Houart, corinne.houart@kcl.ac.uk