Short Description

The successful candidate will work with Professor Li Fong Yau Sam on  Multi-omics studies in cardiovascular disease. The main responsibilities of the position include multi-omic (metabolomic, glyco/glycoproteomic, and metallo/metalloproteomic) characterization of serum/plasma/ platelets to determine how changes in profiles at the different molecular (even elemental) levels are associated with reactivity, acute coronary syndrome (ACS) and antiplatelet therapy response.

Qualifications / Discipline:

PhD in Chemistry or Biochemistry

Skills:

• Development of LC-MS/MS (SRM/MRM) methods for selective identification/quantitation of peptides and metabolites in cardiovascular diseases patient samples.
• Selection of aptamers by SELEX for bioanalysis and biosensing of biomarkers of cardiovascular diseases
• Identification of glycans, glycopeptides and glycosylation sites by using protein purification and mass spectrometry.

Experience:  

• Bioanalytical assays based on liquid chromatography-tandem mass spectrometry for serum/plasma/platelet analysis and biomarkers discovery
• Molecular biology and biochemistry skills: SDS-PAGE, Western-blotting, PCR, molecular cloning, bacterial protein expression, protein purification (gel filtration, HPLC, ion-exchange, affinity chromatography), and SELEX (aptamer development)