NATIONAL UNIVERSITY OF SINGAPORE

Research Fellow, Multi-Omics Studies

Location
Singapore
Posted
05 Jan 2021
End of advertisement period
05 Feb 2021
Ref
3459244
Academic Discipline
Physical Sciences, Chemistry
Contract Type
Permanent
Hours
Full Time

Short Description

The successful candidate will work with Professor Li Fong Yau Sam on  Multi-omics studies in cardiovascular disease. The main responsibilities of the position include multi-omic (metabolomic, glyco/glycoproteomic, and metallo/metalloproteomic) characterization of serum/plasma/ platelets to determine how changes in profiles at the different molecular (even elemental) levels are associated with reactivity, acute coronary syndrome (ACS) and antiplatelet therapy response.

Qualifications / Discipline:

PhD in Chemistry or Biochemistry

Skills:

  • Development of LC-MS/MS (SRM/MRM) methods for selective identification/quantitation of peptides and metabolites in cardiovascular diseases patient samples.
  • Selection of aptamers by SELEX for bioanalysis and biosensing of biomarkers of cardiovascular diseases
  • Identification of glycans, glycopeptides and glycosylation sites by using protein purification and mass spectrometry.

Experience:  

  • Bioanalytical assays based on liquid chromatography-tandem mass spectrometry for serum/plasma/platelet analysis and biomarkers discovery
  • Molecular biology and biochemistry skills: SDS-PAGE, Western-blotting, PCR, molecular cloning, bacterial protein expression, protein purification (gel filtration, HPLC, ion-exchange, affinity chromatography), and SELEX (aptamer development)

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