Lund University, MAX IV ,
Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 40 000 students and more than 8 000 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.
MAX IV is a Swedish national large-scale research laboratory hosted by Lund University. It provides scientists from Sweden as well as internationally, with state-of-the-art instrumentation for research in areas such as engineering, physics, structural biology, chemistry and nanotechnology. Fully developed it will receive more than 2 000 scientists annually, conducting ground-breaking experiments in materials and life sciences using the brilliant X-ray light.
The FragMAX facility provides a user facility for crystallographic fragment screening at BioMAX, the first operational beamline for macromolecular crystallography at MAX IV. Our aim is to develop a platform which enables users with different levels of experience to routinely achieve actionable screening hits for their targets.
We are seeking to appoint a postdoctoral fellow (2-year appointment) for the FragMAX facility to further develop its current capabilities. This is an exciting opportunity for an aspiring post-doctoral fellow to join an international and interdisciplinary team, which is part of BioMAX and the MX-group. You will develop innovative screening protocols in order to facilitate and accelerate fragment elaboration. This will involve conceptual planning of suitable workflows, as well as testing and implementation of robust experimental protocols. Moreover, you will help to establish best practice data collection protocols for protein-ligand screening which make use of the unique capabilities of BioMAX. You will support users during fragment screening and other experiments and disseminate feedback in order to improve the overall performance of the facility. You are expected to work both independently and in close collaboration with the entire FragMAX and BioMAX teams, as well as with academic and industrial collaboration partners. A willingness to challenge existing paradigms and to explore new avenues would be an asset.
Work duties and areas of responsibility
- Development of innovative screening protocols in order to facilitate and accelerate fragment elaboration
- Establishment of best practice data collection protocols for protein-ligand screening
- User support at the FragMAX screening platform and continuous improvement of relevant processes
- Standard user support at BioMAX
- PhD in a relevant area of structural biology, protein biochemistry or biophysics
- Demonstrated expertise in protein crystallography
- Demonstrated expertise in preparation and analysis of protein-ligand complexes
- Ability to work independently
- Ability to work as part of a team and to collaborate with a wide range of colleagues
- Very good command of spoken and written English
- A record of publishing scientific papers
- Experience with fragment-based lead discovery
- Experience in computational chemistry
- Participate in off-hour work
- Travel to international collaboration partners
- User support outside office hours
- On call services may apply in the future.
Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset. We kindly decline all sales and marketing contacts.