Biotechnology Associate II, YCMD

Connecticut, United States
10 Dec 2020
End of advertisement period
08 Feb 2021
Contract Type
Full Time

Position Focus:

Yale Center for Molecular Discovery (YCMD) is a Yale University core facility focused on high-throughput assay design and screening in microplate formats. We are seeking an experienced and motivated scientist to join our group to support University researchers in their small molecule and siRNA screening efforts. Biotechnology Associate II is expected to provide strong intellectual and technical support under the general guidance of the YCMD Director. He/she/they are expected to perform screening and discovery using Yale's small molecule and siRNA collections, liquid handling instruments, platereader and microscopy-based readout technologies and analysis database. Primary duties include design and optimization of biochemical and cell-based assays in a microplate format, as well as execution, interpretation and documentation of high-throughput screens both independently and as part of the matrixed team. Broad knowledge and experience are highly desired as projects and applications are diverse.

Essential Duties

Actively participate in research design and implementation of high-throughput screening experiments. Design experiments (biochemical, cell-based, image-based), develop methods to adapt to high-throughput protocols, conduct screening, identify and apply relevant statistical methods to assess assay performance and prioritize screen actives. Document all research activities, prepare summary reports, recommend approaches for validation and follow-up.

Simultaneously carry out multiple and diverse research projects, both independently and in collaboration with other YCMD scientists. Coordinate resources and help troubleshoot problem areas.

Document research progress daily on Center’s electronic management system. Present weekly updates to screening team. Document experimental protocols and results for discussion and reporting purposes.

Develop, cultivate and maintain relationships with customers within and outside of Yale community. Communicate effectively with YCMD clients and provide superior support of their projects.

Actively contribute to infrastructure efforts and daily operations of the lab. Set up, run and maintain sophisticated Center instrumentation. Investigate, diagnose and correct system malfunctions. Write Standard Operating Procedures.

Expand and improve Center’s infrastructure and capabilities by anticipating future needs. Evaluate new methods, work with vendors, participate in technology evaluation and improvement projects both individually and as part of the team.

Provide expertise to other researchers regarding high-throughput screening, HTS data integration and analysis, and pathways to genetic and pharmacological probe discovery. Serve as an expert resource for Yale researchers by teaching specialized techniques and analysis methods commonly used in biotechnology and pharmaceutical companies. Develop and teach lectures and hands-on courses, co-teach annual YCMD nanocourses, mentor undergraduate interns.

Develop solutions to research problems through library research and readings of scientific material. Attend scientific seminars and conferences. Contribute scientific data to grant proposals. Author/co-author manuscripts for publication.

Essential Duties

  1. Manages the daily activities of a research resource laboratory. Oversees the scheduling, use, and availability of instrumentation, supplies, and specialized work areas.
  2. Carries out biotechnology research design, develop, and modify procedures and instrument operating programs.
  3. Develops, interprets, and analyzes the results of biotechnological analyses and/or syntheses.
  4. Investigates, analyzes, and evaluates alternative instrumentation, methodologies and techniques to maintain a state-of-the-art biotechnology resource laboratory.
  5. Recommends and develops new protocols and initiates and adapts new techniques to resolve problems.
  6. Conducts research to determine the feasibility and scope of providing new/revised services. Develops and evaluates new techniques and equipment.
  7. Prepares budgets and reports pertaining to laboratory costs and income.
  8. Determines and establishes policies and procedures on laboratory safety consistent with University safety regulations.
  9. May perform other duties as assigned.

Required Education and Experience

Master’s Degree in chemistry, biology, biochemistry, or other related discipline and three years of experience or an equivalent combination of experience and education.

Required Skill/Ability 1:

Ability to work both independently and as part of a matrixed team to manage scientific projects and design and carry out experimental programs. Ability to learn new techniques and manage complex laboratory processes.

Required Skill/Ability 2:

Strong organizational skills, ability to multitask and juggle multiple active projects. Excellent communication and interpersonal skills.

Required Skill/Ability 3:

Deep knowledge of molecular biology and cell biology, tissue culture experience and proficiency with cell-based assays. Knowledge of protein chemistry and biochemical assays. Understanding of microscopy techniques.

Required Skill/Ability 4:

Strong quantitative skills and experience using scientific software for data analysis and statistics.

Preferred Education, Experience and Skills:

Experience with high content microscopy, image analysis, liquid handling, automation and high-throughput screening. Familiarity with bioinformatics and statistical methods to analyze large scale datasets. PhD in Biology, Biochemistry or other related discipline and 2 yrs of experience in academia or biotech/pharmaceutical industry. ​Understanding of protein chemistry and biochemical assays.

Drug Screen


Health Screening


Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. Please visit for additional information on the background check requirements and process.

Posting Disclaimer

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the particular position. Employees will be assigned specific job-related duties through their hiring departments.

Affirmative Action Statement:

Yale University considers applicants for employment without regard to, and does not discriminate on the basis of, an individual’s sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression. Title IX of the Education Amendments of 1972 protects people from sex discrimination in educational programs and activities at institutions that receive federal financial assistance. Questions regarding Title IX may be referred to the University’s Title IX Coordinator, at, or to the U.S. Department of Education, Office for Civil Rights, 8th Floor, Five Post Office Square, Boston MA 02109-3921. Telephone: 617.289.0111, Fax: 617.289.0150, TDD: 800.877.8339, or Email:


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