KINGS COLLEGE LONDON

Research Associate - Mechanism of neuronal cell death

Location
London (Central), London (Greater) (GB)
Salary
£38,304, including London Weighting Allowance
Posted
04 Dec 2020
End of advertisement period
04 Jan 2021
Ref
R6/1644/20-KM
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

We are looking for a new Postdoc to join the lab lab of Manolis Fanto to study the mechanism of neuronal cell death in Frontotemporal Dementia in collaboration with Agnes Nishimura and Sarah Mizielinska at the Maurice Wohl Clinical Neuroscience Institute.

The project will employ cell cultures (including iPSC-derived neurons) to study karyoptosis, a recently defined form of cell death based on destruction of the nuclear lamina. The project focuses on models of C9Orf72-based FTD and ALS and, in particular, on the effects of Di-Peptide-Repeats that accumulate inside the nucleus. Bio-ID proteomics and quantitative cell biology will be used as methodology.

The position is available starting from Jan 2021 for up to 29 months. The recruited fellow will also be encouraged to apply for additional funding. We are looking for a highly motivated candidate with a strong background in either cell cultures or biochemistry, capable of working independently on this project, whilst integrated into a larger group. Enthusiasm, determination, resilience, and ability to work independently and as part of a team are essential, as well as good experimental proficiency as evidenced by first author publications or manuscript under consideration.

References

Baron O et al. Curr. Biol. 2017 Dec 4;27(23):3626-3642

Baron O et al. Autophagy. 2018;14(4):722-723

Napoletano F et al. Trends Cell Biol. 2019 Apr;29(4):323-338.

Solomon DA et al. Brain. 2018 Oct 1;141(10):2908-2924

Further information about the lab can be found at the following website.

https://www.kcl.ac.uk/people/manolis-fanto

Contact: Dr Manolis Fanto - manolis.fanto@kcl.ac.uk

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