Research Scientist

Pennsylvania, United States
27 Oct 2020
End of advertisement period
27 Dec 2020
Contract Type
Full Time

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Job Description Summary

The Wangensteen Laboratory is using cutting-edge molecular biology techniques in mouse models to address major knowledge deficits in liver disease mechanisms. We are looking for a highly experienced and motivated scientist with an interest in molecular oncology, immunotherapy, CRISPR/Cas9, high throughput techniques, and in vivo modeling. We aim to recruit a highly ambitious scientist to lead a funded project to discover new therapeutic targets for liver disease and cancer. The ideal candidate will have a PhD or MD with post-doctoral experience and will have a successful background in genomics, signaling, and/or mouse modeling of disease. The project will involve genetic screens using CRISPR/Cas9 technology using methods we have developed in lab, which is leading to a number of impactful publications. This position is suited for an accomplished scientist who is eager to make new discoveries in liver cancer. The goal is to make a real impact on liver disease.

Job Description

We are seeking a PhD Research Scientist who will initiate and manage the development of multiple funded projects at the direction of the Principal Investigator.

The main research pipeline involves design and building of gRNA plasmid libraries for CRISPR screening, injection of these into mice for genetic screening, tissue harvesting and building libraries for high throughput sequencing, bioinformatic analysis of the sequencing results, mechanistic studies to work-up leads from the screens, extensive quality control, careful review of relevant scientific literature, and written and verbal communication of the results.

We are seeking an ambitious, curious, hard-working scientist who enjoys discovery at the bench and who can utilize basic bioinformatic techniques to confirm and extend results.

The P.I. Dr. Kirk J. Wangensteen is a physician-scientist who is specialized in Gastroenterology and Hepatology, and who has been at Penn for more than 9 years. The lab is situated in a highly modern facility, with natural light and easy access to equipment, reagents and cores. The environment is collegial, friendly, and open-minded; we like to explore all great scientific ideas. In addition, Penn has outstanding seminar series and provides numerous career development opportunities.

Position contingent upon funding


Required - At least Masters Degree and 3-5 years of related experience in research, project and people management or equivalent combination of education and experience.

Preferred - PhD with 3-5 years of related experience in research, project and people management or equivalent combination of education and experience.

Working Conditions

Office, Library, Computer Room; Requires extensive safety

Physical Effort

Typically sitting at a desk or table; Occasional lifting 25 lb. or less

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$50,684.00 - $91,232.00

Affirmative Action Statement 

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements 

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.