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Job Description Summary
The Wangensteen Laboratory is using cutting-edge molecular biology techniques in mouse models to address major knowledge deficits in liver disease mechanisms. We are looking for a highly experienced and motivated scientist with an interest in molecular oncology, immunotherapy, CRISPR/Cas9, high throughput techniques, and in vivo modeling. We aim to recruit a highly ambitious scientist to lead a funded project to discover new therapeutic targets for liver disease and cancer. The ideal candidate will have a PhD or MD with post-doctoral experience and will have a successful background in genomics, signaling, and/or mouse modeling of disease. The project will involve genetic screens using CRISPR/Cas9 technology using methods we have developed in lab, which is leading to a number of impactful publications. This position is suited for an accomplished scientist who is eager to make new discoveries in liver cancer. The goal is to make a real impact on liver disease.
We are seeking a PhD Research Scientist who will initiate and manage the development of multiple funded projects at the direction of the Principal Investigator.
The main research pipeline involves design and building of gRNA plasmid libraries for CRISPR screening, injection of these into mice for genetic screening, tissue harvesting and building libraries for high throughput sequencing, bioinformatic analysis of the sequencing results, mechanistic studies to work-up leads from the screens, extensive quality control, careful review of relevant scientific literature, and written and verbal communication of the results.
We are seeking an ambitious, curious, hard-working scientist who enjoys discovery at the bench and who can utilize basic bioinformatic techniques to confirm and extend results.
The P.I. Dr. Kirk J. Wangensteen is a physician-scientist who is specialized in Gastroenterology and Hepatology, and who has been at Penn for more than 9 years. The lab is situated in a highly modern facility, with natural light and easy access to equipment, reagents and cores. The environment is collegial, friendly, and open-minded; we like to explore all great scientific ideas. In addition, Penn has outstanding seminar series and provides numerous career development opportunities.
Position contingent upon funding
Required - At least Masters Degree and 3-5 years of related experience in research, project and people management or equivalent combination of education and experience.
Preferred - PhD with 3-5 years of related experience in research, project and people management or equivalent combination of education and experience.
Office, Library, Computer Room; Requires extensive safety
Typically sitting at a desk or table; Occasional lifting 25 lb. or less
Job Location - City, State
Department / School
Perelman School of Medicine
$50,684.00 - $91,232.00
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