KINGS COLLEGE LONDON

Postdoctoral Research Associate in Imaging Biology

Location
London (Greater) (GB)
Salary
Grade 6, £38,304 - £45,026 per annum, including London Weighting Allowance
Posted
13 Oct 2020
End of advertisement period
13 Nov 2020
Ref
R6/1323/20-AU
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

King’s College London with its 200 years of heritage is recognized today as a world-leading research university, ranked 7th in the 2014 Research Excellence Framework. We understand the need to turn original thinking into everyday application, encouraging curiosity to develop work that makes an impact on society and global issues. Great names from King’s are continuing to change the world.

We have an exciting position for a qualified postdoctoral Research Associate to undertake a ground-breaking preclinical, British Heart Foundation-funded, research in the School of Biomedical Engineering at St Thomas' Hospital (STH). The project will run in collaboration with the Victor Chang Cardiac Research Institute in Sydney and the Baker Heart and Diabetes Institute in Melbourne Australia, the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid and the Molecular Imaging Center in Torino.

The research aims to detect high-risk coronary atherosclerotic plaques by identifying dysfunctional elastin synthesis and/or breakdown, first in mouse and pig models of atherosclerosis and later in patients with coronary artery disease. The project will utilize and further develop a novel tropoelastin-specific MRI probe; utilize advanced MRI protocols and ex vivo bench-based techniques to investigate whether: (i) Molecular MRI of tropoelastin can distinguish between high-risk and stable atherosclerotic plaque both in mouse and swine models; and (ii) whether the tropoelastin specific probe allows differentiation between high-risk and stable plaque in patients with coronary artery disease. This study will answer the clinically important question whether MRI can selectively identify high-risk coronary plaque and guide treatment aimed at reducing the risk of myocardial infarction in a precision medicine approach.

Located in the heart of London, King’s is the hub of a global network of strong academic connections and collaboration, with prestigious international partnerships within and across disciplines – scientific and medical, social and creative. King’s is investing in the highest calibre of talent to drive the university forward to achieve its greatest potential. The very best from the United Kingdom and across the globe are invited to join King’s. We are looking for a strong commitment to teaching and research, to push the boundaries of knowledge, influence the future and create a lasting impact.

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