Research Fellow, Cardiovascular Biomarker Research
The School of Biological Sciences invites applications for a Research Fellow in Cardiovascular Disease Biomarker Development. We would like to recruit an enthusiastic and creative scientists/researchers to develop an immuno-based assay/diagnostic kit for early detection of subclinical cardiovascular disease (CVD).
CVD is the leading cause of death globally, and contributes to 1 out of every 3 deaths in Singapore. Moreover, more than half of patients suffering an acute clinical event such as heart attack or stroke don’t have any traditional risk factors such as high cholesterol, high blood pressure, or diabetes. We recently discovered a set of new pathogenic plasma biomarkers for accurate detection of subclinical CVD. A diagnostic/screening kit based on the biomarker will enable early detection of asymptomatic patients in the general population at risk of CVD for intensive medical management for primary prevention. This diagnostic kit will radically change the mortality and morbidity of CVD, reduce healthcare and socioeconomic burden and also increase the health span in human. You are invited to join us to develop this disruptive method to reduce risk of CVD and to increase health span in mankind. We have generated hybridoma cells for specific mAbs for investigating the functional role of the biomarkers in arterial diseases. The mAbs will be used to develop the immuno-assays and immune-imaging method for detecting the biomarker in clinical samples, and animal tissues from CVD animal models.
The Research Fellow will be responsible to:
- Develop immuno-based assay to quantify plasma proteins
- Perform biochemical assays, cell culture and animal experiments
- Perform data and statistical analysis
- Supervise junior research staff and graduate student
- Draft manuscript
- PhD degree in biomedical research, immunology, biomarker research
- Experience with protein chemistry and immune-assay
- Highly motivated and responsible candidate
We regret that only shortlisted candidates will be notified.