- Full Time
We are looking for a new Postdoc to join the lab of Manolis Fanto to study the mechanism of neuronal cell death in Frontotemporal Dementia in collaboration with Agnes Nishimura and Sarah Mizielinska at the Maurice Wohl Clinical Neuroscience Institute.
The project will employ cell cultures (including iPSC-derived neurons) and Drosophila to study karyoptosis, a recently defined form of cell death based on destruction of the nuclear lamina. The project focuses on models of C9Orf72-based FTD and ALS and, in particular, on the effects of Di-Peptide-Repeats that accumulate inside the nucleus. Proteomics, fly genetics and quantitative cell biology will be used as methodology.
The position is available starting from September 2020 for up to 30 months. The recruited fellow will also be encouraged to apply for additional funding. We are looking for a highly motivated candidate with a strong background in either cell cultures or Drosophila genetics, capable of working independently on this project, whilst integrated into a larger group. Enthusiasm, determination, resilience and ability to work independently and as part of a team are essential, as well as good experimental proficiency as evidenced by first author publications or manuscript under consideration.
Baron O et al. Curr. Biol. 2017 Dec 4;27(23):3626-3642
Baron O et al. Autophagy. 2018;14(4):722-723
Napoletano F et al. Trends Cell Biol. 2019 Apr;29(4):323-338.
Solomon DA et al. Brain. 2018 Oct 1;141(10):2908-2924
Further information about the lab can be found at the following website.
Contact: Manolis Fanto (firstname.lastname@example.org