Project Officer, Bioinformatics/Bio-Data Science/Machine Learning
A Project Officer (Bioinformatics/Bio-Data Science/Machine Learning) position is currently available in the Bio-Data Science and Education Laboratory, School of Biological Sciences, Nanyang Technological University, Singapore (https://gohwils.github.io/biodatascience/).
Batch effects are usually only dealt with in late stage of analysis. We think there is value in early intervention. Using mass-spectrometry-based proteomic data, the first goal is to therefore, examine at what point resolution of batch effects provides greatest positive impact (raw data, peptide identification, inferred protein). Secondly, ambiguously mapped peptides are often discarded prior to protein mapping but also carry useful information regarding batch-effect loading, this project examines the cost, in terms of being able to estimate batch effect, of discarding this information source. Thirdly, missing values are common in proteomics data and are usually resolved by imputation prior to batch effect correction, imputation approaches usually ignore the batch covariate, such that batch effects can creep into proteins due to careless imputation.
Your primary role is in would be to help examine the extent of this problem. In collaboration with our lab members, you will also help develop solutions.
In addition, you will also partake in various machine learning and AI-driven initiatives involving the use of MS data in clinical diagnostics. You will have the opportunity to work on cutting edge data from next-generation proteomics platforms such as DIA-SWATH and DIA-PASEF.
- Bachelor’s degree (at minimum) in the areas of Computational Biology/Bioinformatics/Biostatistics/Bioengineering/Data Science/Computer Science/Machine Learning is required
- Interested applicants who do not fall under these specific subject categories, but can substantiate interest with relevant experience or achievements are also welcome to apply
We regret that only shortlisted candidates will be notified.
Hiring Institution: NTU