KINGS COLLEGE LONDON

Research Associate

Location
London (Central), London (Greater)
Salary
£38,304, including London Weighting Allowance
Posted
03 Sep 2020
End of advertisement period
21 Sep 2020
Ref
R6/1079/20-KM
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

We are looking for a new Postdoc to join the lab lab of Manolis Fanto to study the mechanism of neuronal cell death in Frontotemporal Dementia in collaboration with Agnes Nishimura and Sarah Mizielinska at the Maurice Wohl Clinical Neuroscience Institute.

The project will employ cell cultures (including iPSC-derived neurons) and Drosophila to study karyoptosis, a recently defined form of cell death based on destruction of the nuclear lamina. The project focuses on models of C9Orf72-based FTD and ALS and, in particular, on the effects of Di-Peptide-Repeats that accumulate inside the nucleus. Proteomics, fly genetics and quantitative cell biology will be used as methodology.

The position is available starting from September 2020 for up to 30 months. The recruited fellow will also be encouraged to apply for additional funding. We are looking for a highly motivated candidate with a strong background in either cell cultures or Drosophila genetics, capable of working independently on this project, whilst integrated into a larger group. Enthusiasm, determination, resilience and ability to work independently and as part of a team are essential.

References

Baron O et al. Curr. Biol. 2017 Dec 4;27(23):3626-3642

Baron O et al. Autophagy. 2018;14(4):722-723

Napoletano F et al. Trends Cell Biol. 2019 Apr;29(4):323-338.

Solomon DA et al. Brain. 2018 Oct 1;141(10):2908-2924

Further information about the lab can be found at the following website.

https://www.kcl.ac.uk/people/manolis-fanto

Contact: Manolis Fanto (manolis.fanto@kcl.ac.uk)

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