Senior Research Investigator
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Job Description Summary
The Senior Research Investigator (SRI) will take a leadership role in designing, overseeing, executing and interpreting advanced experiments whose end goal is the development of novel genetic therapies for neuromuscular diseases. Experimentation will include cutting-edge AAV-based gene therapy, pathological and state-of the-art physiological assessments of muscle and cardiorespiratory dysfunction in rodent and large animal models of neuromuscular disease.
The SRI will play crucial roles in all aspects of gene therapy product development and implementation including overseeing workflow and supervising and training lab personnel as necessary. The successful candidate will also be responsible for packaging research findings into publications, grants and presentations for academic and non-academic forums. The SRI will report to Research Director (Dr. Justin Percival) to assist the Principal Investigator (Dr. Jim Wilson) in developing new gene therapies for neuromuscular diseases.
Continuation of all GTP positions is contingent upon grant funding.
The Gene Therapy Program (GTP) is entering a new era of unprecedented growth and opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have already set the stage for successful treatments and possibly even cures for devastating genetic diseases, once considered incurable.
The GTP of the University of Pennsylvania, is headed by Dr. Jim Wilson, a leader in the development of innovative vector technology for close to three decades. The GTP has emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
We are currently looking for a Senior Research Investigator (SRI) to advance our neuromuscular disease gene therapy portfolio.
As an SRI, Translational Research, you will be involved in translational research projects in one or more therapeutic areas. In each case, you will be working in the setting of large interdisciplinary teams, where you will function independently in the execution of the experiments and collaboratively with members of other teams. Working independently, you will design, perform, optimize and implement complex in vitro and in vivo experiments in rodents, dogs, and nonhuman primates within specified timelines; provide cross-organizational support for essential laboratory functions; write and review protocols and standard operating procedures; prepare manuscripts and presentations and establish key collaborations.
This position offers the opportunity to interface broadly internally and externally with diverse scientific specialties as well as academic and industry partners. Joining GTP offers scientific professionals the unique opportunity of making discoveries that could progress from bench to bedside and ultimately lead to cures for devastating diseases.
A minimum of 5 years’ experience after completion of the Ph.D. degree in the field of any of the following: small or large animal models of neuromuscular or muscle disease, cardio-respiratory physiology, molecular physiology, gene therapy, or related field. Experience in methodologies of molecular and cellular biology preferred. The successful candidate must thrive in a multi-disciplinary team environment, have excellent analytical, written and oral communication skills, and the ability to prioritize in a fast-paced environment.
Job Location - City, State
Department / School
Perelman School of Medicine
$35,568.00 - $204,000.00
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