UNIVERSITY COLLEGE DUBLIN (UCD)

Post-doctoral Research Fellow Level 1

Location
Dublin
Salary
£34223.33 - £34714.89 per annum
Posted
08 Jun 2020
End of advertisement period
22 Jun 2020
Ref
012448
Contract Type
Temporary
Hours
Full Time

Applications are invited for a temporary post of a UCD Post-Doctoral Research Fellow Level 1 within UCD School of Medicine

Bechet's disease (BD) is a heterogeneous multifactorial auto-inflammatory condition characterised by recurrent episodes of oral and genital ulceration, uveitis and skin lesions, with less frequent involvement of the gastrointestinal tract, large blood vessels and central nervous system. Two recent studies have reported monogenic mucocutaneous ulcerative syndromes with similarities to BD, in six
unrelated families caused by loss-of-function mutations in NF-kB pathway genes.

We have identified 5 Irish families with a very similar illness, primarily involving childhood-onset chronic oral and genital ulcers. In the largest, a three generation family, whole exome sequencing revealed segregation of a mutation in RELA (p65) with the condition. The mutation involves a cytosine deletion causing a His487ThrfsTer7 frameshift resulting in a truncated protein of 492 amino acids compared with wild-type RELA of 551 amino acids. Crucially, the mutation interrupts the two C-terminal RELA transactivating domains.

The research objectives are:

  1. To determine the biological effects of the RELA His487ThrfsTer7 mutation on NF-activities such as inflammation and apoptosis.
  2. To use whole exome sequencing to identify potentially causative mutations in 4 families.
  3. To undertake appropriate biological studies to determine genotype-phenotype associations.

This study will give novel information on both the genetic basis and biological mechanisms of an uncommon, but increasingly recognized auto-inflammatory condition.

This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator. The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.

Salary Scale: €37,874 - €38,418 per annum
Appointment on the above range will be dependent on qualifications and experience

Closing date: 17:00hrs (local Irish time) on 22nd June 2020

Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.

UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.