UNIVERSITY OF BRISTOL

Research Associate, School of Cellular and Molecular Medicine

Location
Bristol, United Kingdom
Salary
£33,797 - £38,017 per annum
Posted
04 Jun 2020
End of advertisement period
02 Jul 2020
Ref
ACAD104563
Contract Type
Permanent
Hours
Full Time

Job number ACAD104563
Division/School School of Cellular and Molecular Medicine
Contract type Open Ended
Working pattern Full time
Salary £33,797 - £38,017 per annum
Closing date for applications 02-Jul-2020

We wish to recruit a Research Associate to be part of a multidisciplinary team investigating and evaluating new approaches to detect Mycobacterium tuberculosis infection in resource-limited settings.

The post is funded by the UK Engineering and Physical Sciences Research Council and will be held jointly between the Schools of Physics and Cellular and Molecular Medicine (CMM) and is a collaboration with the Kenya Medical Research Institute (KEMRI). The post is available for 18 months with potential funding from the 1st August 2020.

The key duties for the postholder will be to generate and characterise a series of modified superparamagnetic nanoparticles (SPIONs) based upon ferritins, and investigate their interactions, and those of a related series of derivatised fluorescent carbon dots (FCDs) with target Mycobacteria. The RA will produce, and subsequently derivatise, recombinant ferritins; characterise these materials using biophysical approaches including electron microscopy, light and X-ray scattering, and superconducting quantum interference device (SQUID) magnetometry; and investigate their interactions with target bacteria. The successful applicant will also be expected to prepare applications for time at the Diamond Light Source and other large scale facilities elsewhere in Europe.

Candidates should have a PhD in a Physical (Chemistry, Physics) or Life Sciences (Biochemistry, Microbiology) discipline awarded or soon to be awarded; or equivalent professional qualification/experience. They should have a strong background in recombinant protein production and characterisation and/or in biophysics/soft matter physics methods. Moreover the successful candidate will be passionate about interdisciplinary working, able to communicate clearly and effectively across a diverse team, be willing to contribute to the scientific direction of the project and disseminate its outputs and have excellent organisational skills.

For informal enquiries please contact Dr Annela Seddon (Annela.seddon@bristol.ac.uk); or Dr Jim Spencer (jim.spencer@bristol.ac.uk).

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

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