Associate Director, Upstream Process Development

Pennsylvania, United States
11 May 2020
End of advertisement period
11 Jul 2020
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Full Time

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Job Profile Title
Associate Director E

Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Job Description

Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide.

The Vector core is on the hunt for an Associate Director, Upstream Process Development to manage the upstream manufacturing of clinical vectors for internal clinical studies.

As the Associate Director, Process Development, you oversee and participate in upstream manufacturing, process optimization, and process development efforts for clinical grade Adeno-Associated Viral Vectors (AAV). You will manage and lead the activities of a small team of upstream technologists, manage tech transfer activities with sponsors and CMO's, and interface with external sponsors.


  • Masters Degree in Biology, Virology, Immunology, or related field with 3-5 year relevant academic (e.g. post-doctoral) or industrial experience required (or combination)
  • PhD strongly preferred 
  • Extensive knowledge of upstream manufacturing and process development of biologics required
  • Mammalian cell culture experience required
  • Experience working in a GMP environment strongly preferred
  • Ability to manage multiple projects, supervise staff and work collaboratively to achieve goals required
  • Excellent oral/written communication skills required

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$72,837.00 - $138,391.00

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.