Research Specialist A

Pennsylvania, United States
10 Apr 2020
End of advertisement period
10 Jun 2020
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Full Time

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Job Description Summary

Research performed in the Garden Immune Regulation Laboratory ranges from basic research at the molecular and cellular level to preclinical testing and clinical trials. Under supervision, the individual will work on an outstanding project to advance antigen-specific immunosuppressive treatment strategies for myasthenia gravis by adoptive transfer of chimeric antigen receptor (CAR) regulatory T cells, leveraging a rodent model of the disease we have developed.

Job Description

The individual will perform various tissue culture, immunology, and molecular biology experiments and work with rodents, observing principles of excellent animal husbandry. The individual must be capable of independent work, while being an engaged and collaborative member of the laboratory team. Good communication skills are essential. Data analysis, short-term project planning, and careful record-keeping are of great importance. Preference will be given to candidates with experience in molecular biology, immunology, and animal handling.

The responsibilities of the Research Specialist will include:

  • Generate new CAR constructs and lentiviral packaging
  • Manufacture lentiviral engineered CAR regulatory T cells for functional assays, characterization by flow cytometry, and therapeutic evaluation in rodent models
  • Conduct animal experiments, including injection, tissue sample collections, and clinical scoring
  • Data recording, analysis, interpretation, and troubleshooting
  • General technical support to enable the laboratory to function effectively
  • Perform additional duties as assigned

A Bachelor’s Degree and 0 to 1 year of experience or equivalent combination of education and experience is required. A BA/BS in Biology is preferred. Experience in immunological techniques, cell culture and animal models is expected; additional experience in molecular biology and biochemical techniques is highly desirable. Evidence of research experience should include laboratory bench experience, and where appropriate, scientific publications and presentations. Ability to learn new techniques and to follow existing protocols is critical. Evening and weekend work is periodically required. Position is available immediately. 

Position is contingent on continued funding.

A cover letter is required along with your resume.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
School of Veterinary Medicine

Pay Range
$35,568.00 - $57,600.00

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.