Stanford University, Cancer Cellular Therapy (CCT) is seeking a Life Science Research Professional 2 to perform complex functions and activities involved in translational research conducted at Cancer Correlative Science Unit (CCSU) and independently conduct a portion of the research project(s).

The Mackall laboratory works on enhancing the effectiveness of existing cancer immunotherapies and on developing novel immunotherapies that are tested in cell-based immunotherapy clinical trials at Stanford hospital.  Cancer Correlative Unit’s goal is to develop correlative science test menu and perform assays on clinical samples, utilizing novel technologies to identify biomarkers of response and accelerate mechanistic research.  We have been working on validating and scaling up cutting-edge assays such as CyTOF single cell proteomics, 10 x genomics single cell transcriptomics, ATAC-seq epigenomics to be performed on cohorts of patients undergoing cellular therapy such as CART infusion.  Correlative studies are critical for the development and assessment of new cell-based immunotherapies. The successful candidate will independently perform portion of the research, help develop new protocols and assist other researchers. Assays associated with this position includes but is not limited to flowcytometry and FACS sort, DNA isolation, RNA isolation and making DNA library. Other job duties include maintaining excellent lab records, report weekly to supervisor, effectively communicate experimental results to the team and the principal investigator, and train other lab personnel as needed.

Duties include:

• Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
• Independently conduct complex (lab and/or field) translational research to gather data for a portion of a major research project.
• Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols
• Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
• Participate in multidisciplinary teams across different faculties or schools.
• Perform ongoing literature review to remain current with new procedures and related research
• Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
• Oversee supply under supervision of principal investigator or business manager.
• Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
• Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.

*- Other duties may also be assigned

DESIRED QUALIFICATIONS:

Experience performing flow cytometry, cell sort, DNA, RNA isolation, PCR, qPCR and knowledge using Diva, Flowjo or Cytobank, Graph-pad Prism

Bachelor’s degree in biological sciences, immunology, or chemistry

Master’s degree in biological sciences, immunology, or chemistry

EDUCATION & EXPERIENCE (REQUIRED): 

Bachelor's degree in related scientific field and two years of relevant work experience; or Master’s degree in a related scientific field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

• Comprehensive understanding of scientific principles.
• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
• Strong analytical skills and excellent judgment.
• Ability to maintain detailed records of experiments and outcomes.
• Ability to work under deadlines with general guidance is essential.
• Excellent organizational skills and demonstrated ability to accurately complete detailed work.

PHYSICAL REQUIREMENTS*:

• Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
• Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
• Rarely climb, scrub and mix or operate hand and foot controls.
• Must have correctible vision to perform duties of the job.
• Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours
• Ability to lift heavy objects weighing up to 50 pounds.
• Ability to work in a dusty, dirty, and odorous environment.
• Position may require repetitive motion.

*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS:

• May require working in close proximity to blood borne pathogens.
• May require work in an environment where animals are used for teaching and research.
• Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
• Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
• May require extended or unusual work hours based on research requirements and business needs.

  WORK STANDARDS:

• Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
• Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
• Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University’s Administrative Guide, http://adminguide.stanford.edu.

Additional Information

• Schedule: Full-time
• Job Code: 4952
• Employee Status: Regular
• Grade: G
• Department URL: http://cancer.stanford.edu/
• Requisition ID: 86238