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Posted Job Title
Process Development Associate Scientist

Job Profile Title
Resource Technologist C

Job Description Summary

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Job Description

Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO's in vector production and is expanding to conduct state-of-the art process development.

We are looking for a Process Development Associate Scientist, to lead process optimization of established upstream and/or downstream manufacturing process for viral vectors.

As Process Development Associate Scientist, you will independently design experiments to optimize upstream or downstream manufacturing processes. You will update existing protocols/SOP's and batch records to reflect optimizations. You will execute pilot experiments to validate newly scaled up/out upstream or downstream manufacturing processes under the director of Process Development Scientists, Associate Directors, or Directors. You will be able to use sound scientific and engineering principles to troubleshoot experiments and to suggest updates to process protocols/SOP's and batch records. You will assist with the technology transfer of new or updated processes to the manufacturing group as well as participate in upstream or downstream manufacturing activities of viral vectors.

You will work both  independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with upstream and downstream biologics manufacturing, tissue culture, column chromatography and other purification processes.

Qualifications:

• BS Degree in Biochemical/Chemical Engineering, Biochemistry, Biology, or related disciplines + 5 to 7 years of relevant experience.
• Must have experience in mammalian cell culture, tangential flow filtration, and/or column chromatography required.
• Experience in biologics manufacturing preferred.
• Knowledge of process development concepts for biological manufacturing; principles of various engineering disciplines helpful.
• Ability to operate in a fast-paced, multi-disciplinary environment.
• Must be an independent thinker, meticulous, detail oriented, and analytical.
• Must be highly motivated, have excellent organizational, communication and interpersonal skills.
• Must be able to work independently and as part of a multi-disciplinary team.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$50,684.00 - $91,232.00

Affirmative Action Statement

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements

Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.