KINGS COLLEGE LONDON

Research Associate

Location
London (Greater)
Salary
Grade 6, £38,304 per annum, inclusive of £3,500 per annum London Allowance.
Posted
24 Oct 2019
End of advertisement period
24 Nov 2019
Ref
R6/2394/19-RL
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

ZAP is a cellular antiviral protein that inhibits the replication of a diverse range of viruses including retroviruses, alphaviruses, hepatitis B virus and influenza A virus. It binds to regions of viral RNA containing CpG dinucleotides to repress translation and target it for degradation. TRIM25 and KHNYN interact with ZAP and are necessary for its antiviral activity against some viruses. These proteins may also be able to inhibit viral replication independent of ZAP. 

A full time postdoctoral research associate position is available immediately to be co-supervised by Dr Chad Swanson and Professor Stuart Neil. The postdoctoral associate will characterise how ZAP and its cofactors restrict viral replication. This project will focus on how ZAP, TRIM25 and KHNYN inhibits negative strand RNA viruses, including influenza A virus, though other viruses may also be studied. 

The successful candidate will have a PhD in virology or molecular biology, be hardworking with a proven track record of publication as a primary author of scientific paper(s) in well-regarded scientific journals, and have a particular interest in tackling fundamental questions regarding the mechanisms of viral replication. Previous experience with negative strand RNA virus reverse genetics systems will be an advantage.

This posts is a fixed-term contract for 2 years.

This is a full-time position.

The selection process will include a presentation.

For an informal discussion to find out more about the role please contact: Dr Chad Swanson (chad.swanson@kcl.ac.uk) and Professor Stuart Neil (stuart.neil@kcl.ac.uk).

To apply, please register with the King’s College London application portal and complete your application online.

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