The human fungal pathogen Candida albicans, the causative agent of thrush, causes severe morbidity in millions of individuals worldwide. However, the host and fungal mechanisms that determine susceptibility or resistance to mucosal candidiasis are unclear. Our recent work reveals that Candida albicans pathogenicity and immune activation is driven by the production of candidalysin, a cytolytic peptide toxin. Furthermore, several host proteins have been identified as being critically important in immune activation by candidalysin.
In addition, several new potential peptide toxins have been identified in other human fungal pathogens that may have similar functions to candidalysin. A Research Associate/Fellow trained in membrane biology, funded by a Wellcome Trust Investigator Award, will employ cellular, biochemical and imaging technologies to investigate the interactions between these novel fungal peptide toxins and host cell membranes.
The successful applicant will be based in the laboratories of Professor Julian Naglik and Dr Jonathan Richardson at King’s College London. You will produce independent, original research within the group and aid in the submission of publications to refereed journals.
This post will be offered on a fixed-term contract until 31 March 2024.
This is a full-time post - 100% full time equivalent.
The selection process will include a panel interview.
For an informal discussion about the role, please contact Professor Julian Naglik; firstname.lastname@example.org
To apply, please register with the King’s College London application portal and complete your application online.