Research Fellow, Centre for Cancer Research and Cell Biology
Application closing date 13/11/2019
Salary £33,797 to £36,914 per annum
Job category/type Research
Queen's University Belfast is one of the prestigious Russell Group of UK research-intensive universities in the UK and Ireland, combining excellence in research and education with a student centred ethos, for our 24,000 students and 4,200 staff, funded through an annual turnover of some GBP 300m. As a driver of innovation and talent, based on excellence and global strategic partnerships, we offer generous employment terms and underpinned by excellent lifestyle benefits including opportunities for family friendly working and support for wellbeing.
Our five core values - Integrity, Connected, Ambition, Respect, Excellence - are shared by our staff and students, representing the expectations we have for ourselves and each other, guiding our day-to-day decisions and the way we behave as individuals in an international organisation.
The Centre for Cancer Research and Cell Biology (CCRCB) is the beating heart of a comprehensive cancer research programme in Belfast, focused on accelerating the delivery of scientific discovery to clinical application. CCRCB is the research hub of the Belfast ECMC and the Belfast Experimental Cancer Medicine Centre (ECMC), operating in partnership with the Belfast Health and Social Care Trust. Our integrated clinical and scientific programmes address clinically unmet needs.
Our principal objective is to promote evidence-based, innovative clinical trials in order to underpin improved patient outcomes in high incidence solid tumours of Gastro-Intestinal, Prostatic, Breast and Ovarian origin, and in specific Blood Cancers. Our unifying research theme is to develop translational outputs, in the form of biomarkers and/or novel therapeutic strategies that enable our Centre to be at the forefront of personalised cancer medicine in these prevalent diseases.
The Faculty of Medicine, Health and Life Sciences currently holds a prestigious Athena SWAN Silver Award
We are looking for a highly motivated Research Fellow to join the Functional Genomics Group and Drug Resistance Groups in the Centre for Cancer Research and Cell Biology (CCRCB) at Queen's University Belfast. This exciting BBSRC funded post aims to explore novel roles we have recently uncovered for p53 in regulating cell death and tissue homeostasis. Using a combination cell and molecular biology phenotypic assays and functional genomics analyses (e.g. ChIP-seq, RNA-seq, ATAC-seq) of 2D and 3D models you will investigate novel cell death regulatory function of p53 induced complexes homeostasis and cell death.
This is a full time temporary post available until 30 November 2022
The successful candidate must have:
- Hold or be about to obtain a PhD in molecular biology or a related discipline.
- At least three years relevant research experience.
- Experienced in a range of molecular and cellular biology techniques, such as Western blot, immunoprecipitation, flow cytometry, in vitro pull-downs and apoptosis detection techniques, Nucleic acid extraction, RT-PCR, Western blotting, immunofluorescence/IHC.
- Tissue culture experience including working with single-cells (e.g. scRNA-seq, Flow-cytometry).
- Experience with genomic data generation (For example ChIP-seq, RNA-seq, ATAC-seq, Microarray) transcriptional profiling.