Postdoctoral Research Associate in Cardiovascular Sciences
The post holder will report to Professor Catherine Shanahan and will perform research investigating the epigenetic regulation of vascular smooth muscle cell (VSMC) calcification. We have identified a bromodomain (Brd) chromatin remodeling protein as a key regulator of vascular calcification.
This project will identify Brd regulated genes, confirm whether the role of Brd in calcification is through the chromatin remodelling BAF complex and determine the changes in histone acetylation that direct Brd: DNA interactions. We will test the efficacy of novel small molecule inhibitors in preventing calcification both in a novel organoid model and in vivo.
The candidate should have experience in molecular biology, epigenetics and data analysis and a keen interest in multidisciplinary research. Experience in bioinformatics is highly desirable. The successful candidate will join a research group within the BHF Centre of Research Excellence which provides an excellent highly multidisciplinary environment with state-of-the-art equipment and facilities.
Candidates should have, or be about to obtain a PhD in Biological Sciences or a related discipline.
This post will be offered on a fixed-term contract until 31 December 2022
The selection process will include a panel interview.
For an informal discussion to find out more about the role please contact Professor Catherine Shanahan firstname.lastname@example.org
To apply, please register with the King’s College London application portal and complete your application online.