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Postdoctoral Research Associate

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
Grade 6, £38,304 per annum, inclusive of £3,500 per annum London Allowance.
Closing date
3 Nov 2019

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Academic Discipline
Biological Sciences, Life sciences
Job Type
Research Related, Research Associate
Contract Type
Fixed Term
Hours
Full Time

Job Details

In this project the post-doctoral researcher will use Drosophila models to investigate how mitochondrial dysfunction contributes to neurodegeneration. Mitochondrial dysfunction is strongly associated with Alzheimer’s disease (AD) and other dementias. We identified hypoxia inducible factor-1 alpha (HIF-1α) as a key transcriptional regulator of the response to mitochondrial dysfunction in Drosophila neurons (Cagin et al. 2015, PNAS). We also recently showed that mitochondrial dysfunction causes an increase in the metabolite 2-hydroxyglutarate (2-HG), which promotes neuronal dysfunction in Drosophila (Hunt et al. 2019, JCB, in press).

The aim of this project is to determine how HIF-1α and 2-HG combine to cause neuronal dysfunction in the Drosophila nervous system. The postdoc will use genetic and biochemical methods to determine how 2-HG affects HIF-1α in Drosophila neurons. They will also identify genes that are mis-regulated by 2-HG and HIF-1α in neurons using RNA-seq and ChIP-seq. Overall, this project will answer fundamental questions about the response to mitochondrial dysfunction and identify new potential therapeutic strategies for neurological diseases.

More details on the Bateman lab are here: https://www.kcl.ac.uk/ioppn/depts/bcn/Our-research/Neurodegeneration/bateman

This post will be offered on a fixed-term contract for 17 months.

This is a full-time post - 100% full time equivalent.

The selection process will include a panel interview, an assessment, a presentation.

 

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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