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Post Doctoral Research Associate in BREX and Bacteriophage-Bacteria

Employer
DURHAM UNIVERSITY
Location
Durham, United Kingdom
Salary
Grade 7, £33,797 - £40,322
Closing date
3 Oct 2019

Department : Department Of Biosciences

Position Type : Research

Grade 7, £33,797 - £40,322

Applications are invited for a Postdoctoral Research Associate in Microbiology and Biochemistry with a particular emphasis on bacteriophage-bacteria interactions. Studies using bacteriophages (phages) underpin modern genetics and molecular biology. Phage biology is currently enjoying a renaissance owing to the widespread interest in CRISPR-cas and other phage-resistance mechanisms, including the newly discovered BREX systems.

BREX loci contain 6-10 genes including a conserved methyltransferase. BREX methylates the host at specific recognition sequences, but the mechanism of BREX phage protection is not yet understood.

This research programme contains three interconnected objectives: (1) Define the essential components and interactions within BREX loci using an E. coli model; (2) Define the biochemical activity and structure of BREX components and/or complexes; (3) Define how bacteriophages become BREX-resistant. These aims will be achieved using a range of techniques including microbiology, molecular biology, biochemistry, structural biology (X-ray crystallography, cryo-EM) and genomics. The project will be supported by two PhD studentships.

The post is full time and fixed term for 36 months. The successful candidate will be supervised by Dr Tim Blower (Department of Biosciences) at Durham University, who can be contacted for informal enquiries on timothy.blower@durham.ac.uk.

Closes midday on : 03-Oct-2019

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