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Postdoctoral Research Associate

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater) (GB)
Salary
Grade 6, £34,189 to £37,345 per annum, plus £3,500 per annum London Allowance.
Closing date
15 Sep 2019

Job Details

Dr Anny Devoy and Dr Marc-David Ruepp are seeking a Postdoctoral Research Associate to carry out an MRC-funded project to identify pathomechanisms that lead to mitochondria dysfunction in early-stage amyotrophic lateral sclerosis (ALS). This position will be based within the UK Dementia Research Institute (DRI) centre at King’s College London (www.kcl.ac.uk/ioppn/depts/bcn/dri/lab-groups). The DRI is a national consortium focused on cutting-edge dementia research funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK (www.ukdri.co.uk). 

The project is focused on the identification of the toxic ‘gain-of-function’ interaction(s) of mutant FUS protein that drive mitochondrial dysfunction in FUS-ALS. The role will involve generating proteomics datasets of the FUS interactome from a novel in vivo model of FUS-ALS, followed by spatial characterisation of key protein-protein interactions using cutting edge super resolution imaging techniques, in both the in vivo model and human IPSC-derived neurons carrying ALS-associated mutations. We are therefore looking for a highly motivated and dedicated candidate with good knowledge in protein biology and imaging, ideally super resolution imaging such as SIM or STORM.

This is a unique collaborative project that will involve working closely with the group of Dr Helene Plun-Favreau at the Institute of Neurology, UCL (https://www.ucl.ac.uk/ion/research/departments/neurodegenerative-disease/people/dr-helene-plun-favreaus-group).  While based primarily at KCL, the candidate will be expected to spend a period of time in the first year working within Dr Plun-Favreau’s group at UCL to generate the initial interactome datasets. Thus, the successful candidate will experience working within two of the top neuroscience research centres in the UK. 

Please note this collaborative MRC-funded project will employ TWO postdoctoral scientists, one each for KCL and UCL. We therefore strongly encourage interested applicants to also investigate the second post based at UCL. Applicants are welcome to apply for both posts simultaneously.   

 This post will be offered on a fixed-term contract for 3 years.

This is a full-time post - 100% full time equivalent.

The selection process will include a panel interview, a presentation.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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