Postdoctoral Research Associate
Dr Anny Devoy and Dr Marc-David Ruepp are seeking a Postdoctoral Research Associate to carry out an MRC-funded project to identify pathomechanisms that lead to mitochondria dysfunction in early-stage amyotrophic lateral sclerosis (ALS). This position will be based within the UK Dementia Research Institute (DRI) centre at King’s College London (www.kcl.ac.uk/ioppn/depts/bcn/dri/lab-groups). The DRI is a national consortium focused on cutting-edge dementia research funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK (www.ukdri.co.uk).
The project is focused on the identification of the toxic ‘gain-of-function’ interaction(s) of mutant FUS protein that drive mitochondrial dysfunction in FUS-ALS. The role will involve generating proteomics datasets of the FUS interactome from a novel in vivo model of FUS-ALS, followed by spatial characterisation of key protein-protein interactions using cutting edge super resolution imaging techniques, in both the in vivo model and human IPSC-derived neurons carrying ALS-associated mutations. We are therefore looking for a highly motivated and dedicated candidate with good knowledge in protein biology and imaging, ideally super resolution imaging such as SIM or STORM.
This is a unique collaborative project that will involve working closely with the group of Dr Helene Plun-Favreau at the Institute of Neurology, UCL (https://www.ucl.ac.uk/ion/research/departments/neurodegenerative-disease/people/dr-helene-plun-favreaus-group). While based primarily at KCL, the candidate will be expected to spend a period of time in the first year working within Dr Plun-Favreau’s group at UCL to generate the initial interactome datasets. Thus, the successful candidate will experience working within two of the top neuroscience research centres in the UK.
Please note this collaborative MRC-funded project will employ TWO postdoctoral scientists, one each for KCL and UCL. We therefore strongly encourage interested applicants to also investigate the second post based at UCL. Applicants are welcome to apply for both posts simultaneously.
This post will be offered on a fixed-term contract for 3 years.
This is a full-time post - 100% full time equivalent.
The selection process will include a panel interview, a presentation.