Researcher in the field of dental biomaterials

Location
Leuven, Louvain (BE)
Posted
16 Aug 2019
End of advertisement period
15 Sep 2019
Contract Type
Fixed Term
Hours
Full Time

DEVELOPING A NEW GENERATION OF BIOSAFE COMPOSITES FOR TOOTH RESTORATION - FOCUS ON BIOCOMPATIBILITY, TOXICITY AND BIODEGRADATION

(ref. BAP-2019-563)

Internationally, the BIOMAT group has achieved great renown for its research in the field of dental biomaterials. BIOMAT has built a vast expertise in material development, physico-mechanical and chemical biomaterial characterization and mechanistic research on biological interactions of biomaterials. BIOMAT’s research expertise in dental biomaterials supported by the scientific expertise from existing research collaborations with bioengineers, chemists, environmental health scientists and material scientists, along with the research equipment available at KU Leuven, altogether form the structure needed to succesfully run this project and to provide data that can serve as a good basis for future applied research in the research domains involved.

Project

Resin composite is currently the most used material in dentistry, enabling minimally invasive and nearly invisible tooth restoration. Besides nano-dustissues, there are also particular safety concerns regarding the potential release of the endocrine disruptor ‘bisphenol A’ (BPA). BPA can be present incomposites as production contaminant and/or degradation product, originating from BPA-based monomers, such as BisGMA. The latter serves as a polymerization‘cross-linker’ and is a main monomer matrix ingredient of many of today’s commercial dental composites (and other resin-based dental materials). Itsbi-aromatic BPA core imparts mechanical strength, rigidity and hydrophobicity to the composite matrix. Thanks to a recent KU Leuven research & development breakthrough, BPA-free bi-aromatic diols have been synthesized from wood and appear very promising to replace BisGMA in dental composite, with even the potential to further improve physico-mechanical properties of composite.

This multidisciplinary project, combining bioengineering technology with dental material science, aims to develop a new generation of biosafe dental composites based on bio-produced BisGMA monomer alternatives. The project involves the production as well as the biocompatibility, physico-mechanical and chemical property testing of experimental BPA-free composite formulations as compared to current dental composite material standards.

Profile

The candidate should be a holder of a university degree (such as ‘Master in Biomedical Sciences’, ‘Dentistry’, ‘Medicine’, ‘Biology’, ‘Bio-science Engineering’,‘Pharmacy’, etc.) and should have a particular interest in biomaterial and cellbiology research (biocompatibility, toxicity and biodegradation). The candidate must be able to work in team, as he/she will work in close collaboration with another PhD student, who will focus on biomaterial physico-mechanical and chemical property testing. The candidate is expected to conduct the project towards a PhD degree (4 years) and needs to enroll in the KU Leuven PhD program of the Biomedical Sciences Doctoral School.

Offer

  • Attractive 4-year full-time employment contract - continuation after the first 6 months/year is dependent upon a positive evaluation.
  • Supervision by recognized experts and access to state-of-the-art research infrastructure.
  • Highly innovative research project aiming to improve dental composite technology.
  • Training in complementary skills via participation at local and network-based events.
  • Salaried position according to the KU Leuven salary rates for PhD students.

Interested?

For more information please contact Prof. dr. Kirsten Van Landuyt, tel.: +32 16 33 24 38, mail: kirsten.vanlanduyt@uzleuven.be or Mr. Ben Mercelis, tel.: +3216332414, mail: benjamin.mercelis@kuleuven.be.

You can apply for this job no later than September 15, 2019 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.