PhD in Molecular Immunology

Location
Leuven, Louvain (BE)
Posted
09 Jul 2019
End of advertisement period
31 Jul 2019
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Fixed Term
Hours
Full Time

PHD POSITION IN MOLECULAR IMMUNOLOGY (KU LEUVEN, BELGIUM)
(ref. BAP-2019-493)

Last modification : Tuesday, July 9, 2019

The host lab:
The Adaptive Immunity laboratory at KU Leuven is looking to extend its team with a talented and motivated PhD student.

The international group led by Prof Susan Schlenner has two main study areas: 

  • To understand the regulatory mechanisms of Treg lineage stability/plasticity using an holistic, in vivo approach in order to understand stability/plasticity-determining molecular networks at epigenetic/transcriptional/proteomic levels. We are using new mouse models to gain an insight of unprecedented depth into the molecular switches that determine a Tregs’ fate. This knowledge is invaluable to preclinical studies that aim at regulating Treg suppressive activity or Treg numbers in inflammatory diseases or cancer. 
  • To study the role of epitranscriptomic regulation in the murine immune system we have generated a number of novel mouse strains. The impact of epitranscriptomic modulation of immune cell development, homeostasis and activity is at its infancy and we are taking first important steps in deciphering the regulatory role of transcript modifications.

The lab has strong expertise in Crispr/Cas, mutant mice generation and flow cytometry, as well as a strong focus on in vivo work. We are heading the genome engineering platform and the FACS core facility. Furthermore, we have implemented single cell RNAseq and alternatives of it (PsiSeq/PerturbSeq), and have excellent expertise on molecular techniques such as cloning. 

In our laboratory we nurture an environment of collaboration and support, trying to provide every lab member with the best of opportunities to follow their ambitions within the lab as well as their career ambitions. 

The host institution: 
KU Leuven is Belgiums leading university and is continuously in the top 10 of the worlds’ most innovative universities. Core facilities with highest quality of service include the genomics core, the molecular small animal imaging centre (MoSAIC), MutaMouse (genome engineering service), cell imaging core (CIC), animal facility, microscopy core, electron microscopy, FACS core, mass spectrometry center, phosphoproteomics analysies, and many more. In this very collaborative environment, special equipment such as ultracentrifuges, Seahorse Extracellular Flux Analyzer, Typhoon Biomolecular Imaging and many more are shared across departments.

Website unit 

Project

Project:

You will pursue an independent research project onthe role of epitranscriptomic regulation in T cells. Novel mutant mice havebeen developed for you to kick-start. This project encompasses a number oftechniques such as the handling of mice, ex vivo analysis (in vitro assays/flowcytometry), transcriptional analyses, lentiviral work as well as moleculartechniques such as vector design and cloning.

Profile
Please feel encouraged to apply for this position if the following applies to you:

  • Strong interest in adaptive immunity
  • You have some practical background in molecular cloning and flow cytometry
  • You have interest in Bioinformatics and maybe even some experience.
  • You finished your masters with honours/distinction and have less then 2 years of work experience.

Offer

We offer: 

A four-year PhD position (1 year followed by evaluation) in our international team with excellent guidance as well as support to submit a PhD fellowship application. 

Please submit the following documents: 

  • Motivation letter
  • CV (including list of techniques that you are proficient in)
  • Names of 2-3 referees

Interested?
For further questions please email  susan.schlenner@kuleuven.be

We look forward to your application!

You can apply for this job no later than July 31, 2019 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be