Postdoctoral Research Assistant, Blizard Institute

4 days left

London, United Kingdom
£37,411 - £41,683 per annum (Grade 5)
21 Jun 2019
End of advertisement period
21 Jul 2019
Contract Type
Full Time

Department: Blizard Institute
Salary: £37,411 - £41,683 per annum (Grade 5)
Location: Whitechapel
Closing date: 10-Jul-2019


Applications are invited for the role of Postdoctoral Research Assistant in the Blizard Institute, Queen Mary University of London. The Blizard Institute is the largest institute of Barts and the London School of Medicine and Dentistry and aims to deliver excellence in all aspects of research, teaching and clinical service.

Modelling of Neurodevelopmental defects and Alzheimer’s Disease in human induced pluripotency stem cells (hiPSC) using trisomy 21 (Down Syndrome) as extreme phenotype approach

The Postdoctoral Researcher will lead the project in quantitatively characterizing the phenotypes we recently established in 2D and 3D/organoid systems, using extensive immunohistochemical and immunofluorescent approaches. This will lead to deeper understanding of the pathomechanisms of DS and Alzheimer’s dementia, and the design of hi-throughput chemical screening assays for phenotype correction. In addition, a range of genetic models of Alzheimer’s dementia (partial trisomies and CRSPR-reduced single gene trisomies) will be available. The Researcher will lead on the newly starting project funded by the EU-Joint Pathways in Neurodegeneration.

We are looking for postdoctoral research assistant with a track record of accomplishment (either during the PhD studentship, or during a previous postdoctoral research) demonstrating ability in the field of cell modelling of neurodevelopmental and/or neurodegenerative diseases. Experience with quantitative histochemical and immunofluorescent techniques, extensive experience with human neuroanatomy and human post-mortem brain samples handling, cell culture experimentation, and characterization of cell phenotypes are essential, as well as experience with experimental animals. Experience in work with human stem cells and their injection into experimental animals would be an advantage. A PhD or equivalent is Cell Biology or related field and undergraduate degree or equivalent in relevant subject are also essential.

The lab (http://www.icms.qmul.ac.uk/Profiles/Paediatrics/Nizetic%20Dean.htm) is located within the modern, futuristic Blizard building, attached to the Royal London Hospital campus. The Blizard institute is a 400 researcher’s strong hub of cell and molecular science, and is equipped with the latest state-of-art FACS and high-content and high-throughput confocal microscopy equipment manned core facilities. 

The post is full time initially for 24 months, and a further extension may become possible pending the outcome of grant applications under review. Starting salary will be in the range of £37,411 - £41,683 per annum inclusive of London Allowance. Benefits include 30 days annual leave, pension scheme and interest-free season ticket loan.

Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.

Please include your CV and a current list of publications with your application. Any specific questions should be addressed to Professor Dean Nizetic, d.nizetic@qmul.ac.uk or call 020 7882 2275

Details about the institute can be found at www.blizard.qmul.ac.uk

To apply for the role, please click the ‘apply’ button below.

The closing date for applications is 10th July 2019.

Interviews are expected to be held shortly thereafter.

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