Research Fellow in Structural Biology
Are you looking to apply your skills in Structural Biology or in Molecular Virology to gain a new molecular understanding of how influenza virus pandemics emerge? Are you keen to develop new skills in cutting edge electron microscopy and cell imaging techniques?
We are looking for an outstanding postdoctoral research fellow to join the Fontana lab at the University of Leeds. The fellow will be part of a Human Frontier Science Program team that aims to unravel the molecular mechanisms of influenza ribonucleoprotein (RNP) transport from the nucleus to the plasma membrane and assembly into RNP bundles, a process that is critical for reassortment of the viral genome and the emergence of influenza pandemics. This project is a collaboration between experts in the molecular biology of influenza viruses (Naffakh, Institut Pasteur, France), biophysicists (Cisse, MIT, USA), and electron microscopists (Fontana, University of Leeds). The fellow will take advantage of a cellular system, which resembles the natural respiratory tissue targeted by influenza virus (developed by the team at Pasteur) to image influenza virus RNP transport, using cryo-focused ion beam combined with cryo-electron tomography and subtomogram averaging. The fellow will also develop electron microscopy in situ hybridization (EMISH) methods to identify individual vRNPs inside the infected cell. The information gathered from these approaches will be combined with dual-colour single molecule fluorescence in situ hybridization (FISH) in live cells (developed by the team at MIT).
You must have a PhD (or near to completion - meaning after you have submitted your initial version of your thesis) in molecular virology and/or structural biology and experience in molecular biology of RNA viruses and/or cryo-electron microscopy of macro-molecular complexes.
To explore the post further or for any further queries you may have, please contact:
Location: Leeds - Main Campus
Faculty/Service: Faculty of Biological Sciences
School/Institute: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology
Grade: Grade 7
Salary: £33,199 to £39,609 p.a.
Due to funding limitations, it is unlikely an appointment will be made above £33,199 p.a.
Working Time: 100%. We will consider flexible working arrangements
Post Type: Full Time
Contract Type: Fixed Term (Fixed-Term for up to 3 Years - external funding)
Release Date: Monday 03 June 2019
Closing Date: Wednesday 03 July 2019
Downloads: Candidate Brief