Postdoctoral Research Associate, Department Of Biosciences
Department Of Biosciences
Grade 7 (£33,199 - £39,609)
Applications are invited for a Research Associate to work on a BBSRC-funded project: “Sphingolipid biosynthesis in the parasitic apicomplexan protozoa: divergent enzymes in key host: pathogen interactions”.
Our previous work has demonstrated that host sphingolipid biosynthesis plays only a minor role in the proliferation of the model apicomplexan parasite Toxoplasma gondii (Pratt et al., Mol. Biochem. Parasitol., 2013). This indicated that the de novo protozoan sphingolipid biosynthetic pathway is crucial for parasitism, and recently we have demonstrated that this has an unusual evolutionary origin (Mina et al., J. Biol. Chem., 2017). Working as part of an established team focused on the functional studies of the enzymes involved in pathogen lipid biosynthesis, the appointed researcher will utilise the in-house availability of genetically modified Toxoplasma to characterise the role of protozoan sphingolipid biosynthesis in parasite proliferation.
In addition, they will continue the establishment of platforms to facilitate the further biochemical and biophysical analyses of the target enzymes in vitro. Together, the results and tools generated will establish the pathway as a tractable potential drug target for further exploration in a range of apicomplexan pathogens of importance to human and animal health and food security.
The post is fixed term for 3 months and the successful candidate will be working with Dr Paul Denny (PI) and Dr Ehmke Pohl (CoI) at Durham University.
Closes midday on : 03-Jul-2019