Resource Technologist Clinical Vector

Location
Pennsylvania, United States
Posted
29 May 2019
End of advertisement period
29 Jul 2019
Ref
40-32137
Contract Type
Fixed Term
Hours
Full Time

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. http://www.med.upenn.edu/

The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO’s in vector production and is expanding to conduct state-of-the art process development.

Due to significant growth, the Vector Core is looking for a new, Process Development (PD) Associate, to support downstream purification production of and projects related to clinical AAV vectors.

As a PD Associate, you will be responsible for the production and purification of research grade and GMP-comparable AAV vectors for IND-enabling Pharmacology and Toxicology studies. You will be documenting your activities on batch records for QA review. You will also participate in process optimization and development research activities.

You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with upstream and downstream biologics manufacturing, tissue culture, column chromatography and other purification processes.

Bachelors Degree (BS) in Biochemical/Chemical Engineering, Biochemistry, Biology, or related disciplines + 3 to 5 years of relevant experience or an equivalent combination of education and experience required.

Must have experience in upstream or downstream biologics manufacturing.

Experience in downstream biologics manufacturing preferred.

Must have experience with tissue culture, column chromatography, or TFF.

Must be an independent thinker, meticulous, detail oriented, and analytical.

Must be highly motivated, have excellent organizational, communication and interpersonal skills.

Must be able to work independently and as part of a multi-disciplinary team.

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.