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A Research Specialist A position is available in Moiseenkova-Bell lab at Perlman School of Medicine at the University of Pennsylvania. Our laboratory studies a class of membrane proteins known as Transient Receptor Potential (TRP) ion channels. They are a distinct family of Ca2+-permeable non-selective cation channels that have been implicated in a diverse range of cellular processes, including pain and temperature sensation, neuronal development, cardiovascular and renal pathophysiology, and cancer. We utilize cryo electron microscopy (cryo-EM) to determine the structural basis of TRP channels activation, inhibition and desensitization mechanisms. Structural information on TRP channels allows to enhance our understanding of their function at the molecular level, whereby improving therapeutic strategies and drug design.
The position has two components, (1) Carrying out laboratory research experiments, and (2) Providing day-to-day laboratory support. Research activities will involve molecular biology, membrane protein biochemistry and cryo electron microscopy. Laboratory support activities will include ordering supplies, coordinating equipment repair, preparing common lab reagents and maintaining general lab operation.
A Bachelor’s Degree and 0 to 1 year of experience or an equivalent combination of education and experience required. Skill sets required are excellent written and verbal communication, self-mediated drive, and a proactive approach to daily tasks. Further, candidate qualities should include a strong motivation to learn, tendency to pay exceptional attention to detail, and the ability to multitask. Previous laboratory research experience is preferred, but not required.
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