A postdoctoral research fellowship position is available in the laboratory of Dr. Jacob Kitzman in the Department of Human Genetics and Department of Computational Medicine and Bioinformatics. Our group develops new genomics technologies to detect and study the functional impacts of genetic variation upon traits in health and disease. The specific focus of this position will be to develop deep ‘functional maps’ of human disease genes using cutting-edge, high-throughput experimental approaches including deep mutational scanning and CRISPR domain scanning.
The successful candidate will establish mammalian cell culture and organoid functional assays for several genes, adopting and improving approaches developed in our lab and elsewhere. The candidate will be expected to gain familiarity with the primary literature in areas relevant to the genes selected for functional studies, as well as in sequencing and genome editing technologies generally.
Finally, the applicant will be expected to contribute to supervision of students and technicians to work collaboratively on this and related projects.
This position requires a highly motivated, organized individual with a demonstrated track record of innovation and independent direction. Applicant must hold a Ph.D. in a genomics-related field such as Genetics, Molecular Biology, Biochemistry, or Bioinformatics. Extensive experience in standard molecular biology, cloning techniques, and tissue culture techniques is required. Some experience with biological data analysis tools and general bio-computing skills (e.g., Linux, python, jupyter notebook, R) is required.
Prior experience with genome editing (e.g., using CRISPR/Cas or TALEN technologies) and massively parallel sequencing (e.g., Illumina) is desirable.
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Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
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