The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.
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This Research Specialist B position will work on developing and testing nanotechnologies for the treatment of acute critical illnesses, such as ARDS (acute inflammation of the lungs), sepsis, stroke, and others. Our lab packages drugs and gene therapy vectors into nano-scale carriers (~100 nanometers in diameter), and targets them to the organ and cell types of interest using affinity moieties (e.g., antibodies), cell-hitchhiking, and medical devices. We test these in mouse models of acute critical illness, as well as large animal models, and in ex vivo human organs that were deemed unsuitable for organ transplant. We often partner with existing companies and spin out our own start-ups, giving the opportunity to gain experience interacting with industry.
Lab website: www.brennerbioengineeringlab.com
The applicant will perform a broad range of experiments in mouse work, molecular and cell biology, and pharmacology. The methods will include: mouse models of disease followed by organ harvest within 24 hours; histology of mouse organs; flow cytometry of dissociated mouse organs; pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution); production of nanoscale drug carriers according to protocols we already have well worked out.
The Research Specialist B will have the opportunity to design experiments and new medical technologies on their own, but with as much advice from the Principal Investigator as required. This independence and freedom therefore requires an applicant with significant lab experience.
The applicant will also keep accurate notebooks, perform data analysis, and assist in publication preparation. Additional duties will include participating in general laboratory activities such as lab meetings, ordering, and maintenance.
A Bachelor’s Degree and 1 – 3 years of experience or an equivalent combination of education and experience required.
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.