The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.
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The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. http://www.med.upenn.edu/
The Research Specialist A position will provide technical support for advanced in vivo and in vitro experiments in breast cancer research as well as clinical studies conducted under the 2-PREVENT Translational Center of Excellence. The individual will process and catalog patient samples from multiple clinical studies and assist project leaders who are developing approaches for the isolation and analysis of circulating and disseminated tumor cells and DNA (CTC, DTC, ptDNA) from breast cancer patient samples and rodent models. Core responsibilities will include the processing and cataloging of bone marrow and whole blood samples. Additional responsibilities will include assisting senior research staff with extracting and amplifying genetic material from captured CTC/DTCs and independently conducting IHC and IF based experiments designed to screen for DTCs. Research approaches will include the use of inducible animal models of breast cancer and utilize various cell and molecular biology techniques. The individual will also provide technical support for pre-clinical drug studies involving rodent models. Responsibilities will also include breeding colony management, genotyping, histology, survival surgery, and tissue harvest, as well as maintaining records and material stocks. Cell and molecular work may require experience in cloning, PCR, Q-PCR, western and northern blotting, tissue culture, and flow cytometry. Excellent communication and organizational skills are essential as is the ability to work as part of a team and to multi-task in a fast paced work environment.
A Bachelor’s Degree in Biology or a related field and 0 to 1 year of experience or equivalent combination of education and experience is required. Demonstrated proficiency with techniques such as DNA/RNA extraction and purification, PCR, qPCR, RT-qPCR, Immunofluorescence, Immunohistochemistry is highly desirable. Experience with rodent cancer models, tissue culture, and cloning is preferred. Some of the work is done in the University’s animal facility and requires gowning. It would be helpful if the candidate is not allergic to mice and rats. Candidate must also possess good communication, organization and computer skills.
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