NATIONAL UNIVERSITY OF SINGAPORE

Research Fellow: Proteomics

Location
Singapore (SG)
Posted
30 Apr 2019
End of advertisement period
30 May 2019
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Permanent
Hours
Full Time

Research Fellow: Proteomics

Biomedical Institute for Global Health Research and Technology (BIGHEART)

National University of Singapore (NUS)

BIGHEART develops innovative healthcare solutions to address current challenges in health and spark major advancements with societal and economic impact. The SurgiCAL ProtEomics Laboratory (SCALPEL) is a laboratory within BIGHEART with a focus on bringing next generation proteomics based platforms (including Electron Spray Ionisation, MALDI Imaging mass spectrometry and Liquid chromatography) with downstream machine learning capabilities into the clinical arena. The laboratory has collaborations within NUS, NUH and a large industry collaboration with Bruker Daltonics. We aim to interrogate subcellular fractions including the secretome, patient derived organoids, surgical effluent, exosomes and single cells. 

Job Description

We are seeking a passionate and self-motivated Research Fellow to join our laboratory. A major aspect of the work is developing innovative techniques in low volume, low abundance protein discovery prior to high sensitivity mass spectrometry analysis. Work will be performed together with the mass spectrometry team in the facility.

Key Responsibilities

Experimental analysis of samples by mass spectrometry including sample preparation, bioanalytical work, analysis and reporting of protein/peptide expression, and method development

  • Compiling and analysing proteomics data
  • Data management and data services
  • Coordination of core facility projects

The work involves a combination of flexible and routine tasks and places a great emphasis on independence, initiative, precision, and planning. The group works in close contact with clinical teams.

Requirements:

  • PhD degree in analytical chemistry, biochemistry, biotechnology or in a related field
  • Extensive hands-on experience in the laboratory and ability to follow SOPs in daily work
  • Competence/experience in MS-based clinical proteomics research
  • Excellent communication and organisational skills
  • Good knowledge (both speaking and writing) of English
  • Development-oriented with personal drive and patience
  • Able to collaborate with people of different backgrounds and levels, both within the group and with users from other disciplines
  • Experience in MS as an analytical method is preferred
  • Hands-on experience with LC and MS instruments is preferred
  • Understanding of analytical chemistry will be a merit
  • Ability to analyse proteomics data is preferred
  • Strong interest to work in centralised shared research infrastructures is preferred

To apply, please send your CV to Dr Glenn Bonney (glenn_bonney@nuhs.edu.sg). Only shortlisted candidates will be contacted. 

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