Karolinska Institutet, The Department of Medicine, Huddinge

We are seeking ambitious individual to join the research group of Yenan Bryceson to understand immune cell differentiation and immunogenetic susceptibility to severe diseases. This is studied through a combination of patient samples, high-throughput sequencing, molecular biology, and in vivo models.

The applicant that is hired will, as part of a team, further explore and functionally characterize regulatory elements in normal immune cells as well as in malignant immune cells purified from patients. The main task of the candidate will be bioinformatics analysis of high-throughput sequencing data including whole genome, RNA-seq, ATAC-seq, ChIP-seq, single cell RNA-seq, and HiC sequencing data. The overall goal is to understand the impact of regulatory elements in the development of normal and malignant cells.

The research group

The Bryceson laboratory consists of 7 postdocs, 2 PhD students and one technician dedicated to research immunity and genetic susceptibility to disease. We already have large datasets encompassing trancriptome and various histone activity on a range of immune cell subsets from multiple donors. In addition, we have a program for whole genome sequencing of patients with suspected primary immunodeficiencies. The candidate will be an integral part of interdisciplinary research activities in the laboratory. The research group is internationally competitive, holding research grants from, among others, the European Research Council.

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases.

The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe. The laboratory offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. In the Bryceson group (http://www.ki.se/en/medh/yenan-bryceson-group), you will be working in a very international and interdisciplinary research environment, where collaborative efforts are encouraged.

Entry requirements

The 50% postdoctoral position is available for two years. Depending on scientific progress, additional extensions are possible.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. 

• PhD in Bioinformatics
• Strong programming skills such as Perl, Python, JAVA, C/C++ programming knowledge in Unix/Linux environments
• Proven experience of software development in Bioinformatics
• Experience with advanced analysis of high-throughput sequencing data such as ChIPseq, RNAseq, HiC or whole-genome sequencing data
• Proven expertise in biostatistics, large-scale computing, biological data analysis
• Be able to work independently, manage priorities, and accurately produce results in a timely manner
• Excellent spoken and written English

A strong publication track record including recent high impact publications is expected. Good communication skills with the ability to present results clearly, work co-operatively as part of a team as well as independently with strong attention to detail are also essential. We will accord special weight to academic skills, particularly demonstrated excellence in research, a strong dedication, and excellent communication skills.

Application process

An employment application must contain the following documents in English or Swedish

• A letter explaining the interest in the position and how the applicants background and experience would be relevant for the project.
• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A synopsis of current research work (no more than one page)

Division

The Department of Medicine at Huddinge comprises seven units, three research centers and, around 70 independent research groups. Our ambition is to be a leading department within medical research and education. The Center for Hematology and Regenerative Medicine (HERM) is a research unit within the Department of Medicine Huddinge. The research at HERM is focused around translational studies of the immune system. HERM has since its inauguration in 2011 rapidly grown and gained national and international recognition.

Karolinska Institutet is one of the world’s leading medical universities.

Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences.

The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employment     Temporary position longer than 6 months
Contract type     Part-time
First day of employment     According to agreement
Number of positions     1
Working hours     50%
City     Huddinge
County     Stockholms län
Country     Sweden
Reference number     2-2599/2019

Contact     

Yenan Bryceson, Yenan.bryceson@ki.se

Union representative     

Carina Eklund, OFR, carina.eklund@ki.se
Belinda Pannagel, SACO, Belinda.Pannagel@ki.se

Published     26.Apr.2019
Last application date     26.May.2019 11:59 PM CET