Division/School School of Cellular and Molecular Medicine
Contract type Open Ended
Working pattern Full time
Salary £33,199 - £37,345 (Grade I) - £37,345 - £42,036 (Grade J) per annum
Closing date for applications 19-Jun-2019

Multiple Postdoc positions to study Cell Competition in mouse in vivo models and in human in vitromodels

(Senior / Research Associate level)

Several post-doc positions are available in the lab of Professor Eugenia Piddini to study the mechanism and impact of cell competition in tissue homeostasis and in cancer. The aim of the Piddini group is to identify strategies that exploit cell competition to develop novel therapeutic approaches in cancer and in regenerative medicine. Towards that goal our group investigates the mechanism of action of cell competition and its contribution to various pathological conditions. We are funded by the Wellcome Trust and by Cancer Research UK.

Our lab uses a variety of approaches, model systems and technologies including: cell and molecular biology, gene editing and genome wide genetic screening, quantitative live imaging, human primary cells (particularly skin and airway epithelial cells) and stem cells and tumour-derived cell lines, Drosophila and mouse in vivomodels of tumorigenesis.

We are recruiting 3 post-docs to study the mechanisms of mechanical cell competition using cell culture models, and its relevance in vivo using the mouse airway (project in collaboration with Dr Emma Rawlins, University of Cambridge).

We are looking to recruit talented and highly motivated individuals with expertise in cell biology, molecular biology, cell culture, signal transduction and imaging. Experience in one or more of the following is also required: in vivo mouse work (ideally airway epithelia), CRISPR/Cas9 mutagenesis and knock-ins, culture of primary epithelial cells/organoids (preferably skin, liver or airway), quantitative cell biology and image analysis, experience with analysis of deep sequencing data. Applicants should have a substantial track record of productivity and international experience. They should have a PhD in a relevant subject area, or be close to completion of their degree.

Applications should include a CV and a brief statement outlining key areas of expertise and reasons why you would like to join our group. Informal enquiries can be addressed to Professor Eugenia Piddini: email: eugenia.piddini@bristol.ac.uk, tel: +44 (0) 1173312045.  The funds for these posts are available for 2 years in the first instance.

The call for positions will be open until positions are filled with shortlisting starting from June 1^st.

We appreciate and value difference, seeking to attract, develop and retain a diverse mix of talented people that will contribute to the overall success of Bristol and help maintain our position as one of the world’s leading universities.