Karolinska Institutet, NVS

The Department of Neurobiology, Care Sciences and Society (NVS) conducts world leading research in aging, dementia, epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 450 employees and a revenue 2018 of 490 million SEK. It comprises seven divisions, located at Campus Flemingsberg and Campus Solna.

Division

The Division of Neurogeriatrics consits of 16 research groups and approximately 90 employees whereof approximately 20 are PhD students. Our research is focused on Alzheimer´s disease (AD) and other neurodegenerative diseases, and is strongly oriented towards translating findings from basic research into clinical practice.

Research group

The position is placed in the group of Jaan-Olle Andressoo and it is located in campus Flemingsberg. The laboratory’s goal is to develop novel therapeutic approaches by creating tools, which allow increasing endogenous gene expression. Current pharmacopoeia enables to enhance function of only few hundred human proteins. An ability to enhance the function of any gene or pathway of interest would likely be very useful. Recently we have made great progress in this direction by showing that it is possible to use CRE-FLEX and CRISPR-Cas9 systems to conditionally upregulate endogenous gene expression limited to naturally expressing cells. We are now looking for 1-2 post-doctoral colleagues who can help to analyze new knock-in mouse models, where we can study upregulation of endogenous genes on AD outcome. We will also use AAV delivery of CRE and various CRISPR-Cas systems to upregulate endogenous gene expression, preceded by verification of the CRISPR system in appropriate cell-lines. The position/positions are for one year with possibility of extension.

Duties

A successful candidate will independently analyze how developmental or adult onset increase in genetically modified APP expression influences AD pathology and how beta-amyloid miss-folding spreads in adult brain. In parallel, the postdoctoral fellow will analyze how enhancing other genes modulates AD phenotypes using appropriate CRE lines. The postdoctoral fellow will also create RNA libraries for RNA-SEQ analysis from various mouse models and in collaboration from C. elegans samples.

Entry requirements

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.

The Jaan-Olle Andressoo laboratory is looking for a postdoctor with the following qualifications: A Ph.D. in neuroscience or similar, preferably with good knowledge in neurodegenerative diseases. He/she should also have previous thorough theoretical and practical experience in animal experimentation, including behavioral studies and knowledge of crossing different genetically modified mouse lines, cell culture and histological studies. Experience in molecular biology such as protein quantification techniques is a strong merit.

A successful applicant should also have:

• high personal drive and motivation
• strong collaborative attitude
• good organizing skills
• innovative thinking and a high level of independence

Emphasis will be placed on personal suitability.

Application process

An employment application must contain the following documents in English or Swedish:

1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
2. A complete list of publications
3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities.

Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences.

The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Type of employment     Temporary position longer than 6 months
Contract type     Full time
Number of positions     2
Working hours     100%
City     Huddinge
County     Stockholms län
Country     Sweden
Reference number     2-2118/2019

Contact     

Maria Ankarcrona, Professor, Head of Division, 08 524 835 77, maria.ankarcrona@ki.se
Jaan-Olle Andressoo, Associate Professor, +358 50 358 12 13, jaan-olle.andressoo@ki.se
Ulla Cronfalk-Hernlund, Head of Administration, 46 8 524 868 18, ulla.cronfalk-hernlund@ki.se
Maria Staiger, HR Officer, 08 524 837 79, maria.staiger@ki.se

Union representative     

Carina Eklund, OFR, 08-585 826 65
Biborka Bereczky Veress, SACO, 46 70-173 85 75
Henry Wölling, SEKO, 08-524 840 80

Published     03.Apr.2019
Last application date     01.May.2019 11:59 PM CET