KINGS COLLEGE LONDON

UKDRI Research Associate

Location
London (GB)
Posted
15 Mar 2019
End of advertisement period
31 Mar 2019
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Permanent
Hours
Full Time

UKDRI Research Associate

Department :  
 Basic & Clinical Neuroscience

We want to determine the aggregation landscape of TDP-43 in order to understand the contribution of different regions to aggregation.

At the same time, we want to understand the role of post-translational modifications (PTM)s of TDP-43 in the aggregation process because this seems to be a crucial and yet little-explored aspect of TDP-43 aggregation, and their effects could be dominant on the system.

The post holder will take advantage of our previous experience with ataxin-3 and other proteins to introduce ubiquitination, phosphorylation and glycation PTMs as have been observed in FTD/ALS patient tissues and will thus produce differently modified samples and characterize their RNA binding properties and the kinetics of aggregation with advanced biophysical methods including: circular dichroism, NMR, fluorescence, atomic force microscopy, electron microscopy and nanoIR.

Experience in biophysical techniques using advanced microscopy, NMR, biochemistry, and molecular biology approaches is required.

The successful applicants will join established research groups headed by Professor Annalisa Pastore.

This post will be offered on a fixed-term contract for 3 years.

This is a full-time post - 100% full time equivalent

The selection process will include a panel interview, an assessment, a presentation.

To apply, please register with the King's College London application portal and complete your application online.

Grade and Salary :    The salary will be paid at Grade 6, £37,412 to £40,568 per annum, inclusive of £3,223 per annum London Allowance.    
Job ID :    011608
Close Date :    31-Mar-2019
Contact Person :    Professor Annalisa Pastore    
Contact Details :    annalisa.1.pastore@kcl.ac.uk / 020 78485659 

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