Research Associate - St John's Institute of Dermatology
Department : St John's Institute of Dermatology
The successful candidate will work on pre-clinical studies to develop a novel form of cell spray-on ex vivo gene therapy for recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering skin disease with high morbidity and mortality.
Work is divided into three main areas of investigation: (i) generation of proof-of-concept data for successful isolation and expansion of primary skin stem cells; (ii) development of lentiviral vectors for gene therapy of RDEB by targeting primary keratinocyte and fibroblast cells; (iii) optimisation of engraftment of gene-modified keratinocytes and fibroblasts in vivo after spray-on delivery; this phase of the work will be done in part collaboratively with a biotechnology company specialising in cell spray technology. Successful completion of this initial proof-of-concept phase of the project can potentially lead to extension of the post for a further 2 years.
Once all pre-clinical data are obtained, the aim of the project is for clinical translation to first-in-man clinical trials.
This post will be offered on a fixed-term contract for 2 years.
This is a full-time post - 100% full time equivalent
The selection process will include an application process and a panel interview.
To apply, please register with the King's College London application portal and complete your application online.
Grade and Salary : Grade 6, £37,412 - £38,434 per annum, inclusive of £3,223 per annum London Allowance
Job ID : 011306
Close Date : 07-Apr-2019
Contact Person : Dr Su Lwin
Contact Details : Email: firstname.lastname@example.org | Tel: 020 7188 6409