Manager, Rodent Research
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.
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The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. http://www.med.upenn.edu/
The Gene Therapy Program (GTP) and Orphan Disease Center (ODC) are entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. Our R&D organization has a translational infrastructure that includes: technology discovery, specialized immunology assays operating under GLP, a Vector Core/Manufacturing unit that conducts GMP comparable work, and a large non-clinical program for animal testing under GLP including large NHP and rodent vivaria.
Our Animal Models Core is looking for a Manager for our Rodent Research team to ensure the humane care and treatment of laboratory animals.
Reporting to the Senior Director of the Program for Comparative Medicine, you will have responsibilities that fall primarily under 4 categories: Research Support, Regulatory Compliance, Rodent Colony Management, and Finance.
Research Support: Perform specialized experimental procedures as needed (ie, intrathecal dosing; neonatal dosing; stereotaxic surgery, etc). Obtain biological samples as required for in vivo rodent studies; Prepare/administer experimental drugs. Develop study documentation as needed; Ensure that study samples are delivered to the appropriate personnel or diagnostic laboratory. Examine research subjects for morbidity or mortality that could be related to the study and notify clinical research veterinarian. Designate roles for each study to other research staff (veterinary technicians, in vivo technicians, research specialists, etc.). Oversee/perform and schedule necropsies, ensuring the appropriate forms are supplied by the study director; ensure critical supplies and resources are available to support rodent experiments. Maintain accurate documentation of all research related documentation, including but not limited to: health records; animal identification; procedures; sample collection; data analysis; regulatory compliance (Drug Enforcement Agency controlled substances). Maintain records in compliance with Good Laboratory Practices when applicable.
Supervise and train Research Specialists and In Vivo Technicians to conduct various experiments involving laboratory rodents. Assist the Program Manager with daily scheduling of research and GLP studies. Act as a liaison between Research Specialists and Research Directors to evaluate novel AAV therapies for Discovery and Translational research programs in rodent animal models. Ensure documentation is aligned with record keeping requirements.
Monitor animal usage to assure compliance with Federal/State/University policies and notify facility supervisor and/or veterinarian of compliance deviations. Provide timely communications of compliance issues in accordance with IACUC Policy and protocols, GTP SOPs and as directed by GTP Management
Rodent Colony Management:
Work with the Transgenic Colony Manager to ensure rodent resources are available to meet the scientific goals of the department
Help to create purchase requisitions for critical supplies and resources required for study support and submit billing for rodent study related services.
B.A./B.S. in Biology, Molecular Biology, Cell Biology, Biochemistry, Chemistry or in adjacent field with strong scientific background and 3-5 years of post-degree bench laboratory experience, or an equivalent combination of education and experience required.
Experience with Molecular Biology and Biochemistry techniques/assays (cloning, isolations, PCR, ELISA, animal/colony handling/maintenance, and dissection) a must!
Must be willing to learn new techniques involving molecular and cell biology, protein biochemistry, virology, immunology, bioinformatics, and biotechnology.
Must have the ability to follow existing and ability to develop novel protocols and methods; Outstanding interpersonal interaction skills, excellent written and oral communication skills, problem recognition and solving, and organizational skills required.
Prior experience in the field of gene therapy is desirable.
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.