Research Associate in Molecular Microbiology
Division/School Biomedical Sciences Building
Contract type Open Ended
Working pattern Full time
Salary £33,199 - £37,345 per annum
Closing date for applications 24-Mar-2019
Characterizing functional and structural properties of fungal kinases in the pathogenic yeast Candida albicans
We are looking to recruit a talented, enthusiastic and highly motivated postdoctoral researcher to investigate form and function of candidate kinases in the leading fungal pathogen of humans Candida albicans. C. albicans causes ~400,000 life-threatening infections worldwide each year. Mortality rates are unacceptably high, up to 75%, due to the lack of effective antifungal therapies. We previously characterized the virulence potential of fungal-specific kinases and now aim to further investigate their functional and structural properties with the long-term vision of turning them into suitable drug targets
As an integral lab member you will investigate functional properties of candidate kinases, including their activity and target space. In addition to their biochemical characterization, you will conduct structural analysis of at least one high-priority kinase. The project is supported by access to the Faculty of Life Sciences’ outstanding research facilities, including the Proteomics Facility and the Wolfson Bioimaging Facility.
Candidates should have a PhD in Microbiology, Molecular Biology, Cell Biology or Biochemistry. Experience in yeast molecular biology, kinase characterization and/or structural biology are highly desirable. The successful candidate should furthermore have a keen interest in fungal virulence mechanisms, excellent communication skills, and experience in student supervision.
We appreciate and value difference, seeking to attract, develop and retain a diverse mix of talented people that will contribute to the overall success of Bristol and help maintain our position as one of the world’s leading universities.